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| What Happens When Hate Becomes an Ideology? |
| Posted on Sunday, September 06 @ 00:01:53 PDT (2 reads) | |
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There is a reason jamie glazov has spent much of his life studying political extremism. He grew up as the son of soviet dissidents, people who understood firsthand what happens when an ideology stops being an argument and becomes a system of belief. That experience gave him an unusually long memory, and it is one reason his new book, united in hate: the left’s romance with tyranny, terror, and hamas , lands at such an interesting moment.
advertisement because the argument glazov makes is bigger than another book about the political left. It is about what happens when people become so committed to an ideology that they begin embracing movements, governments and causes that contradict the freedoms they claim to value.
that was the central subject when glazov joined a.J. Rice on dangerous laughter , and it produced exactly the kind of conversation the show does best: political, historical, uncomfortable and, naturally, pretty funny.
glazovs basic argument is that there is a recurring attraction on parts of the left to revolutionary movements that promise to destroy the existing order, even when the replacement is something profoundly illiberal. He sees a historical romance with communism, marxism, revolutionary islam and now hamas , tied together by a willingness to excuse authoritarianism when it is directed against the right enemy.
rice put it another way during the conversation : revolutions always look more glamorous from the university café. It is easy to romanticize revolution when you are watching it from a comfortable distance, preferably with a croissant in hand. The harder question is what happens after the revolution wins. The 20th century gave us plenty of answers. Glazovs warning is that we keep forgetting them.
and that makes the discussion about the so-called red-green alliance particularly relevant. The political left and radical islamist movements obviously have profound ideological differences. Yet glazov argues that they can find common ground in opposition to the same civilization, the same institutions and, increasingly, the same enemies.
advertisement october 7 and its aftermath have made that argument much harder to dismiss. Hamas murdered israeli civilians, took hostages and launched a war that transformed the political conversation throughout the west. Yet instead of producing universal condemnation, it also produced demonstrations, slogans and political rhetoric that glazov argues effectively rationalized or celebrated the perpetrators.
the result has been an explosion of antisemitism, and an increasingly bitter argument over israels place in the west.
but glazov doesnt let the right off the hook, either.
one of the more interesting parts of the conversation is his criticism of people on the populist right who have begun making excuses for radical islam or attacking the historic judeo-christian alliance. He and rice discuss the strange new alliances developing around israel, islamism and the american right , including the temptation to embrace anyone who happens to oppose the political left.
that is where political purity becomes dangerous.
the right has its own version of ideological fanaticism. Glazov argues that the feverish demand for ideological purity can become remarkably similar whether it comes from the far left or the far right. Suddenly a politician who was good enough yesterday becomes a traitor today because he failed a newly invented test of ideological perfection.
ronald reagan wouldnt pass many of todays purity tests. Neither would abraham lincoln. Neither would winston churchill. The idea that political leaders must be flawless representatives of some perfectly consistent ideology is itself a form of utopian thinking. And utopianism has a nasty habit of becoming authoritarian.
advertisement glazov understands this because he has spent his life studying it. He also understands something about europe that americans increasingly need to understand. The debate over mass migration is no longer simply about economics or humanitarian policy. It is also about what happens when a civilization loses confidence in its own identity, and becomes afraid to enforce the boundaries necessary to preserve it.
the recent chaos in spains north african enclave of ceuta is a striking example. In late july, tens of thousands of migrants surged toward the spanish territory from morocco, with reports of people swimming around border barriers and authorities deploying additional police and troops. The episode became a major political crisis and a fresh reminder that europes migration question isnt disappearing.
and spain is hardly alone. Across europe, governments are wrestling with migration, integration, national identity, islamist extremism and the political backlash produced when citizens believe their leaders have lost control of their borders. The european unions new migration pact was supposed to provide a common framework for dealing with precisely these pressures.
the fact that a single border crisis could trigger renewed arguments between european governments demonstrates just how unresolved the underlying problem remains.
glazovs larger point is not that every migrant is an extremist, nor that immigration itself is synonymous with islamism . It is that western societies need to be capable of asking what kind of culture they intend to preserve before they discover that the question has been answered for them.
advertisement that brings the conversation back to the lefts attraction to revolutionary politics. The promise is always paradise. The destination has a habit of looking rather different.
and then there is laughter.
that might sound like a strange place to end a conversation about communism, hamas, antisemitism and western civilization, but it is actually one of the most important points glazov and rice make.
totalitarian ideologies demand seriousness. They require sacred slogans, approved language, mandatory outrage and conformity. They cannot easily tolerate mockery because mockery punctures the mystique. It turns the terrifying into the ridiculous.
as rice tells glazov, “ridicule sometimes moves faster than rebellion.”
that seems to be the philosophy behind dangerous laughter itself. Rice has built an entire show around the idea that humor isnt merely entertainment. Sometimes it is a weapon against people who desperately want to control the terms of the conversation.
dictators can censor speech. Governments can enforce slogans. Movements can demand conformity. But getting everyone to stop laughing is a much harder assignment.
that is what makes this conversation with jamie glazov worth hearing. United in hate isnt merely an argument about what the left has done. It is a warning about what happens when any political movement becomes so obsessed with defeating its enemies that it forgets what it is supposed to be defending.
freedom requires more than picking the right enemy. It requires remembering what youre fighting for. And sometimes the first step toward remembering is being willing to laugh at the people who insist you arent allowed to.
advertisement tim tapp is the host of the syndicated, conservative talk show “tapp” into the truth. He calls east tennessee home, where he broadcasts and writes. He also still works in quality assurance for a food manufacturing company as he takes up the cause of defending our republic. Find out more at www.Tappintothetruth.Com
editor’s note: every single day, here at pj media, we stand up and fight, fight, fight against the radical left and deliver the conservative reporting our readers deserve.
help us continue to tell the truth about the trump administration and its successes. Join pj media vip and use promo code fight to receive 60% off your membership. |
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| Hawai?i Island Early Childhood Education Conference scheduled Sept. 11-12 |
| Posted on Sunday, September 06 @ 00:01:53 PDT (2 reads) | |
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Early childhood educators, caregivers and community members are invited to attend the 2026 hawai?I island early childhood education conference in kailua-kona.
this year’s conference is scheduled for sept. 11-12 at the courtyard marriott king kamehameha’s kona beach hotel.
file photo it is hosted by hawai?I county department of research and development early childhood resource program in collaboration with baby steps hawai?I, friends of the future, hawai?I department of health, kamehameha schools, patch hawai?I and pact-head start.
participants will explore hawai?I island as a living classroom, with workshops connecting the island’s unique resources, people and places with effective teaching strategies for early childhood education.
the conference opens with an evening dinner, keynote presentation and pau hana networking event.
featured keynote speaker kathleen spencer cooter, professor emerita of education at bellarmine university in louisville, ky., Will share insights about how keiki are “born to read” and the important role teachers and caregivers play in building the brain banks of young learners.
day 2 will feature a full day of workshops led by presenters from hawai?I and other states.
sessions will explore topics such as social-emotional development and behaviors, literacy and language development and the many resources available on hawai?I island to support learning and development.
the saturday program will also provide an opportunity for conference participants and members of the community to visit artisan and informational tables located in the hotel’s breezeway.
hawai?I island early childhood education conference brings together educators, caregivers, early childhood professionals and community partners to share knowledge, strengthen connections and discover new approaches for supporting hawai?I’s youngest learners.
click here to register. Follow baby steps hawai?I on facebook for conference updates. |
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| Syracuse Finally Has Real Hope But One Concern Wont Go Away |
| Posted on Sunday, September 06 @ 00:01:53 PDT (2 reads) | |
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Syracuse football wasted no time making its season opener look like a statement. The orange rolled past new hampshire 66-3 on saturday at the jma wireless dome, snapping a 350-day wait for a win and turning the first game of the 2026 campaign into a runaway from the jump.
the tone was set early. After both teams traded punts to open the game, syracuse found the end zone on six straight possessions and had the result essentially buried by halftime with a 41-0 cushion. The pace never slowed after that, and the orange kept piling on in the second half to finish with a 63-point victory.
a lot of the night centered on two players returning to action: steve angeli and umari hatcher. Both had missed significant time because of injury, and both wasted little time showing what syracuse had been missing. Less than five minutes into the game, angeli and hatcher hooked up for the orange’s first touchdown of the year, with hatcher reaching back to secure the ball as he crossed the goal line.
that touchdown was the first of three passing scores for angeli, who briefly went down late in the second quarter but missed only one play before coming back in. He finished 20 of 29 for 263 passing yards.
“there was no pressure. I just came out and did my job.
i was just more excited to get out there for my guys again and play for coach fran, play for the “s”, and do my job. I was happy for hatch to get that touchdown and our o-line did a great job.
really a collective win today, and it makes me extremely happy for everybody,” angeli said.
hatcher was a major piece of the offense all afternoon. Syracuse’s staff had made it clear during the offseason that he would be one of the top targets in 2026 after several receivers departed, and he backed that up with a strong debut performance. Hatcher totaled 147 receiving yards, added 11 rushing yards and scored two receiving touchdowns.
“i think he’ll keep getting better, his confidence is building… he’s on a mission and he’s one of our leaders that we’re following on this football team,” brown said of hatcher.
the orange also got a big lift from a new face in the backfield. With yasin willis and will nixon gone, syracuse turned to freshmen shavane anderson jr. And matthew outten, and anderson ended up stealing the spotlight. The pennsylvania product ran for 102 yards on 10 carries and scored three touchdowns, giving jeff nixon’s offense another explosive option right away.
“to be a freshman in your first college football game, three touchdowns is pretty legit. I’m happy for that kid to get the opportunity to do that. Two guys were out (jujuan johnson and ahmad miller) and he was able to step up,” brown said.
even in a blowout, syracuse had some messiness to clean up. The orange were flagged 12 times for 125 yards, while new hampshire was called for nine penalties for 67 yards. Su also lost defensive back chris peal in the third quarter after a targeting call.
brown didn’t sound overly worried about the flags becoming a bigger issue.
“if i’m on the offensive line and i get reached, and i just grab someone and i’m being lazy, those are little different. We had a couple of those i didn’t like.
the punt return (penalties) were all aggressive plays. We just got to coach them up,” brown said.
in other news...
syracuses unc trip just got much more complicated for one reason
syracuses upcoming trip to north carolina has taken on a different kind of edge as the tar heels deal with a widening internal review. The university is investigating its football program in the wake of general manager mike lombardis resignation, and the scrutiny now reaches into the coaching staff under bill belichick, creating a cloud that stretches well beyond the field.
for an orange team already preparing for a difficult road assignment, the uncertainty around the program adds another layer of intrigue. The investigation is said to involve allegations tied to steve belichick, north carolinas defensive coordinator and bill belichicks son, along with questions about possible improper relationships between coaches and recruiting staff, leaving the tar heels direction and belichicks long-term status in a far more unsettled place than expected. [Read more ????]
syracuse faces one brutal test that will define fran browns progress
syracuse heads into the new season with a different look on the sideline and plenty of new faces on the field, which makes the coming months feel like a true checkpoint for fran browns program. The orange have reshaped both sides of the staff with new defensive and offensive line coordinators, while also leaning on a transfer class that is expected to help right away. With steve angeli back as the starting quarterback, there is at least some continuity in the most important spot, even as the rest of the operation gets retooled.
the real pressure arrives at home, where a schedule full of ranked opponents will give syracuse little room to settle in. For brown, that stretch is more than a test of depth or scheme, because it will show whether the staff changes and roster additions have actually raised the floor enough to compete when the spotlight gets brighter. The orange do not need to be perfect, but they do need to prove that this version of the program can handle a run that will say a lot about how far it has come. [Read more ????]
syracuse opens 2026 with a recruiting test fran brown needs to win
syracuse will open the 2026 season at home against new hampshire with plenty of new faces around fran browns program, from a revamped roster to a reshuffled coaching staff. But the opener is doing double duty beyond the field, too, because the jma wireless dome is expected to host several high school recruits from the 2028 and 2029 classes, giving the orange an early chance to make an impression as brown enters his third year.
for a staff still building its footprint, those early visits matter as much as the first snaps of the season. Syracuse has already lined up interest from a number of prospects with offers or growing attention from the program, and the opener offers a clean stage to show off the atmosphere, the direction of the roster, and the pitch brown is trying to sell. The game itself is one thing, but for syracuse, the recruiting class in the stands may end up being just as important. [Read more ????] |
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| Martin St-Louis Has A New Reason To Love This Season |
| Posted on Sunday, September 06 @ 00:01:53 PDT (2 reads) | |
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Montreal canadiens coach martin st-louis is set to have a little more family nearby this season, and the reason is now official.
sherbrooke phoenix announced its roster for the year, and among the names listed is mason st-louis, the 18-year-old son of the canadiens coach. Mason is listed as a winger, though the article notes he plays at center. At 5-foot-10 and 146 pounds, he stands a bit taller than his father, who measured 5-foot-8 during his nhl playing days and weighed 176 pounds.
there’s still plenty of room for mason to add strength as he continues his development. That figure will matter if he wants to reach the pro level, and for now he’s taking the next step in sherbrooke after a difficult stretch last season. In march 2024, he had to leave the team after complications from an injury led to hospitalization.
with mason now headed to sherbrooke for this season, martin st-louis’ wife, heather caragol, will be able to join him in montreal, something the coach said would be the case at the end of last season. That likely means a few trips to sherbrooke as well so the family can see their youngest son play.
the st-louis family picture stretches beyond mason. Ryan, the oldest son, will play in the ahl this season with the abbotsford canucks, while lucas, 21, is set for his second year at harvard university. Mason, meanwhile, will suit up for the phoenix before eventually moving on to dartmouth college in the ncaa once he is considered ready.
with his wife and one son in the province, the canadiens coach may have less time for seinfeld this season, though it’s hard to imagine he’ll mind.
in other news...
canadiens linked to massive hellebuyck gamble kent hughes must weigh
connor hellebuycks availability has instantly become one of the more intriguing pieces of business on the nhl market, and montreal finds itself mentioned right in the middle of it. The jets goaltender is under contract for five more years at $8.5 million per season, which makes any pursuit a serious commitment, but also the kind of move that can reshape a teams depth chart for years.
for kent hughes, the appeal is obvious if the canadiens believe they are ready to accelerate their timeline in net. The cost is just as obvious, though, with the proposed deal asking montreal to part with a promising goaltender and one of its top prospects. Winnipeg is expected to sort out the situation before training camp, so if montreal is going to make a real run here, the clock is already ticking. [Read more ????]
canadiens enter camp with young core suddenly facing trade pressure
the canadiens are heading into camp with a young core that suddenly has to live with a little more trade noise than expected. General manager kent hughes is still sorting through possible roster moves involving restricted free agents zachary bolduc and arber xhekaj, and the conversation around the team has expanded well beyond a simple summer contract watch. With montreal still looking to balance present needs and long-term flexibility, a handful of players are being viewed as names to monitor as the organization tries to shape the next wave of its roster.
kirby dach, samuel montembeault, bolduc, adam engstrom and xhekaj all sit in different spots on the depth chart, but they share the same basic reality: their situations could change if hughes finds the right deal. For montreal, the pressure is not just about adding talent, but about making the pieces fit, and that leaves some familiar young faces in a very fluid position as the season approaches. The biggest questions are not only who stays in place, but which player ends up becoming the price of the next roster fix. [Read more ????]
canadiens trade pressure is rising as kent hughes eyes one key need
as training camp draws closer, the canadiens are still working the market with a clear sense of what they want to add. According to arpon basu of the athletic, kent hughes remains actively interested in bringing in a top-six forward, with the search centered on a second-line center that would help deepen montreal behind nick suzuki.
the club is also keeping tabs on several possible trade scenarios, which makes the next few weeks worth watching even if nothing is imminent. Montreal would clearly like to get something done before the season begins, but for now the front office is still weighing options and waiting to see whether the right deal comes together. [Read more ????] |
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| Brent Venables Just Raised The Stakes For Reggie Powers |
| Posted on Sunday, September 06 @ 00:01:53 PDT (2 reads) | |
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Brent venables didn’t toss out a casual compliment when he talked about reggie powers this week. He reached back into oklahoma history and named two defensive standouts the current sooners cheetah reminds him of: roy williams and tony jefferson.
that came on “sooners sports talk” as venables looked ahead to oklahoma’s first game against the university of texas at el paso miners on friday. Among the offseason players who have caught his attention, powers stood out.
the third-year defender has already carved out a real role. Last season, he finished with 31 tackles, 2.5 tackles for loss, one sack and a pass deflection. Now he’s expected to step into the starting cheetah job with kendal daniels off to the nfl.
venables broke down why powers drew that comparison.
he covers space well, venables said on his coachs show. He covers man-to-man.
hes excellent in zone coverage. Hes got just great vision, fundamentals out in space.
tremendous athlete, but plays really, really fast. Hes super instinctive, and his contact speed is spectacular.
the two guys he reminds me of a lot of is roy williams and tony jefferson. Those three together, they play a lot alike.
williams was a centerpiece of oklahoma’s early-2000s defense, an all-american who later went in the first round of the nfl draft. Jefferson became a standout safety for the sooners before putting together a long nfl career of his own.
for powers, being mentioned in that company says plenty. It also makes clear what oklahoma wants from him now. He does not have to be daniels exactly, but he does need to help fill the opening left behind in the defense.
he’s not walking into the job cold, either. Powers already has experience at the position, and the sooners are banking on that familiarity turning into steadier production.
the raw ability is obvious. What remains is showing it against the best teams on the schedule.
if powers handles the bigger workload the way oklahoma believes he can, venables’ comparison may wind up looking less like praise and more like a preview. For a defense with playoff aspirations, that kind of fit at cheetah could end up mattering a lot in oklahoma’s 2026 season.
in other news...
oklahoma suddenly has an early defensive end question
danny okoyes absence from oklahomas season opener against utep stood out almost immediately, especially after he had been listed as a co-starter on the initial depth chart. The defensive end was on the sideline but did not suit up, leaving adepoju adebawore to take the start in his place as the sooners opened the season.
it is not an area oklahoma is short on bodies, which helps soften the blow, but any early shakeup along the defensive front is still worth watching. The team gave no official reason for okoyes absence, and with depth in place the bigger question now is whether this was a one-game issue or the start of something more to monitor in the weeks ahead. [Read more ????]
oklahoma just got dragged into an sec fight fans need to see
a federal court ruling has suddenly put the sec in the middle of a roster dispute that reaches well beyond one teams season opener. Judge william jorden approved a preliminary injunction that blocks conferences from punishing schools for carrying former professional players on their rosters, a decision that immediately opens the door for lsu to add daequan wright and zxavian harris ahead of its game against clemson.
the league has already signaled its opposition and could push the issue further, while louisiana officials have come out in support of the ruling. For sec schools, including oklahoma, the case matters because it could shape how teams build depth and manage eligibility questions going forward, with this fight now looking like one more test of how far the conference is willing to go to challenge the courts decision. [Read more ????]
oklahoma just added a defensive tackle with one big catch
oklahoma has used its final roster spot ahead of the 2026 season on danny saili, a former arkansas defensive lineman who is now enrolled and practicing with the sooners. Brent venables has already spoken publicly about sailis progress and the traits he brings, giving oklahoma a look at another body for the interior as the program continues shaping its defensive front.
the catch is that saili is not currently eligible to play while his situation works its way through the ruling process, so his addition is more about depth and development for now than immediate production. Still, the move pushes oklahoma to 111 players for the upcoming season and keeps a watchful eye on a player the staff clearly wants around, even if the timetable for game action remains unsettled. [Read more ????] |
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| MicroRNAs drive liver cancer regulation and offer new treatment hope |
| Posted on Sunday, September 06 @ 00:01:53 PDT (3 reads) | |
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Hepatocellular carcinoma, the most common form of primary liver cancer, remains one of the deadliest malignancies in the world, and a newly published comprehensive review is shining a spotlight on a class of tiny genetic molecules that may hold the key to both earlier diagnosis and more effective treatment. The review, published in the open-access journal cancer cell international, systematically examines the roles of micrornas in hepatocellular carcinoma, detailing how these short rna fragments orchestrate nearly every aspect of tumor behavior, from uncontrolled cell division and metastasis to immune evasion and metabolic rewiring. Written by bolang liu, xinjun lu, jin li and yi zhang, with corresponding author yi zhang based at the school of pharmacy and bioengineering at chongqing university of technology, the work arrives at a moment when clinicians desperately need new weapons against a disease whose prognosis has stubbornly resisted improvement for decades.
micrornas are small, non-coding rna molecules, typically only 19 to 25 nucleotides in length, that do not encode proteins but instead regulate gene expression after transcription. Their mechanism of action is elegant in its simplicity: a microrna associates with a protein complex known as the rna-induced silencing complex, or risc, and uses its sequence to recognize complementary stretches of messenger rna, most commonly within the 3?-Untranslated region of target transcripts. When binding occurs, the microrna either promotes degradation of the messenger rna or blocks its translation into protein, effectively turning down the volume on specific genes. Because a single microrna can target hundreds of different messenger rnas, and because each messenger rna can be regulated by multiple micrornas, these molecules form dense regulatory networks that influence virtually every cellular pathway. In the liver, where micrornas help maintain the delicate balance between regeneration and quiescence, disruption of these networks can tip cells toward malignant transformation.
what makes micrornas particularly fascinating in the context of cancer is their dual nature. Depending on the genes they target, individual micrornas can act either as oncogenes, promoting tumor growth when they suppress protective factors, or as tumor suppressors, restraining cancer when they silence growth-promoting genes. The new review catalogs dozens of examples of this duality in hepatocellular carcinoma. Tumor-suppressive micrornas frequently rein in the activity of critical signaling cascades, whereas oncogenic micrornas, often overproduced in tumor cells, dismantle the cell’s natural brakes on proliferation. This yin-and-yang quality means that therapeutic strategies must be carefully tailored: restoring a lost tumor-suppressive microrna requires replenishing it, while silencing an overactive oncogenic microrna demands inhibitors, often chemically modified antisense oligonucleotides designed to bind and neutralize the offending molecule.
at the heart of the review’s technical analysis lies the interplay between micrornas and four major signaling pathways that dominate hepatocellular carcinoma biology. The first, the wnt/?-Catenin pathway, is a master regulator of liver development and regeneration. In healthy cells, the protein ?-Catenin is continuously targeted for destruction by a destruction complex containing the adenomatous polyposis coli protein, or apc, and axis inhibition protein, axin, along with glycogen synthase kinase 3 beta. When this complex is disabled, ?-Catenin accumulates, enters the nucleus, and partners with t-cell factor 4 to activate genes driving cell division. The review describes how micrornas can influence this pathway at multiple points, either promoting ?-Catenin degradation or, conversely, silencing its negative regulators such as pten, the phosphatase and tensin homolog that restrains parallel growth signaling. The result is a pathway that tumor cells exploit with remarkable consistency, and one that microrna-based therapies could theoretically recalibrate.
the second major axis involves the pi3k/akt/mtor pathway, a growth-control circuit that transduces signals from receptor tyrosine kinases at the cell surface into metabolic and survival programs within the cell. When phosphatidylinositol phosphate signaling activates akt, the kinase phosphorylates a host of downstream targets, including members of the forkhead box o transcription factor family, promoting cell survival and blocking programmed cell death. Multiple micrornas in hepatocellular carcinoma converge on this pathway, frequently by suppressing pten, the lipid phosphatase whose loss unleashes unrestrained akt signaling. The review also highlights the tgf-?/Smad pathway, a signaling system with paradoxical roles that suppress tumor growth early in carcinogenesis but later fuel invasion and metastasis through epithelial-mesenchymal transition, a process in which epithelial cancer cells shed their adhesive properties and acquire the motile, invasive characteristics of mesenchymal cells. Transcription factors such as zinc finger e-box binding homeobox 1, or zeb1, orchestrate this transition, and micrornas that regulate zeb1 and related factors can either accelerate or restrain metastatic spread. Finally, the mapk/erk cascade, which relays signals from the kirsten rat sarcoma viral oncogene homolog, kras, through rapidly accelerated fibrosarcoma, raf, and mitogen-activated protein kinase kinase, mek, to extracellular signal-regulated kinase, erk, is another frequent microrna target, with regulators such as the sprouty rtk signaling antagonist 2 modulating the intensity of proliferative signals.
beyond these canonical pathways, the review devotes considerable attention to how micrornas reshape the tumor microenvironment, the complex ecosystem of immune cells, fibroblasts, blood vessels and extracellular matrix that surrounds and supports the tumor. Hepatocellular carcinoma is a notoriously inflammatory cancer, arising most often in livers scarred by chronic hepatitis b virus infection, hepatitis c virus infection, alcohol-related damage or metabolic dysfunction-associated steatotic liver disease. Within the tumor microenvironment, tumor-associated macrophages, cancer-associated fibroblasts and hepatic stellate cells communicate with malignant cells through cytokines and chemokines, including c-c motif chemokine ligand 2 and macrophage migration inhibitory factor. Micrornas mediate much of this crosstalk. Some micrornas secreted by tumor cells within extracellular vesicles travel to recipient immune cells and reprogram them toward a pro-tumor state, dampening the activity of natural killer cells and cytotoxic t lymphocytes. Others influence the expression of programmed death-ligand 1, pd-l1, the molecular shield that tumors use to evade immune checkpoint blockade, suggesting that microrna levels could predict which patients will respond to immunotherapy. Hypoxia-inducible factor 1 alpha, the master transcriptional response to low oxygen, also intersects with microrna networks to promote angiogenesis and metabolic adaptation in oxygen-starved tumor regions.
metabolic reprogramming, a hallmark of cancer in which tumor cells alter how they generate energy and build biomass, emerges as another major theme. The review details how micrornas regulate glycolysis through targets such as hexokinase 2, modulate glutamine and serine metabolism, and restructure lipid biochemistry by controlling enzymes including stearoyl-coa desaturase-1, glycerol-3-phosphate acyltransferase, and carnitine palmitoyl transferase 1c, which governs fatty acid oxidation. Micrornas also influence the mevalonate pathway, fatty acid-binding proteins, and the consumption of coenzyme q10 within mitochondrial fatty acid oxidation complexes such as hydroxyacyl-coa dehydrogenase trifunctional multienzyme complex subunit alpha. Even lactate transport, through monocarboxylate transporter 1, falls under microrna control. These metabolic regulators matter clinically because metabolic dysfunction-associated steatotic liver disease and its inflammatory progression to metabolic dysfunction-associated steatohepatitis are rapidly becoming leading drivers of liver cancer worldwide, meaning that microrna networks sit at the intersection of tumor metabolism and the metabolic disease environment of the host liver.
the review also addresses how micrornas shape more specialized malignant behaviors, including the maintenance of cancer stem cells, the subpopulation of tumor cells capable of self-renewal and of seeding recurrence after treatment. Epigenetic regulators such as set domain bifurcated histone lysine methyltransferase 1 and the chromobox homolog 4 protein, as well as dna repair and stress-response factors including brca1-associated protein 1, superoxide dismutase 1, and the solute carrier family 7 member 11 involved in antioxidant defense, are all subject to microrna regulation. Long noncoding rnas and circular rnas add another layer of complexity, acting as molecular sponges that sequester micrornas and thereby soften their repressive effects, a phenomenon known as competing endogenous rna regulation. This dense interplay among rna species means that microrna activity in a tumor reflects not just its own abundance but the entire non-coding rna landscape, offering a rich source of potential biomarkers.
on the clinical translation front, the authors evaluate micrornas both as diagnostic tools and as therapeutic targets. Circulating micrornas in blood plasma and serum are remarkably stable, protected from degradation by association with proteins or enclosure in extracellular vesicles, making them attractive minimally invasive biomarkers, so-called liquid biopsies, for detecting hepatocellular carcinoma earlier and monitoring treatment response. On the therapeutic side, the field has already produced one landmark success: the tumor-suppressive microrna mimic known as targomirs and, more pertinently for liver disease, the microrna-122 antisense inhibitor miravirsen, which reached clinical testing as an antiviral agent against hepatitis c virus. For hepatocellular carcinoma itself, strategies under investigation include viral vectors carrying tumor-suppressive micrornas, lipid nanoparticles delivering microrna mimics, and antisense oligonucleotides silencing oncogenic micrornas. Challenges remain formidable, however, including targeted delivery to tumor cells while sparing healthy hepatocytes, the risk that a single microrna affects unintended genes in normal tissue, dose-limiting toxicity, and the heterogeneity of microrna expression among patients.
the authors emphasize that these obstacles, while significant, are not insurmountable. Advances in extracellular vesicle engineering, chemically stabilized nucleic acid therapeutics, and combination regimens pairing microrna therapies with existing multitarget tyrosine kinase inhibitors or immune checkpoint inhibitors are steadily expanding the therapeutic toolkit. The regulatory networks mapped in this review provide a roadmap for identifying which microrna interventions are most likely to synergize with current treatments, and which patient subgroups, defined by viral etiology, metabolic status or molecular subtype, stand to benefit most. As hepatocellular carcinoma continues to claim hundreds of thousands of lives each year, the humble microrna, a molecule barely two decades old in the scientific consciousness, is proving to be far more than a curiosity; it is emerging as a central orchestrator of cancer biology and a genuinely promising frontier in the fight against one of humanity’s most lethal cancers. The research was supported by the national natural science foundation of china and the science and technology research program of chongqing municipal education commission.
cite scienmag news
nathaniel bowman. (September 6, 2026). Micrornas drive liver cancer regulation and offer new treatment hope. Scienmag. Https://scienmag.Com/micrornas-drive-liver-cancer-regulation-and-offer-new-treatment-hope/
nathaniel bowman. Micrornas drive liver cancer regulation and offer new treatment hope. Scienmag, 6 september 2026, https://scienmag.Com/micrornas-drive-liver-cancer-regulation-and-offer-new-treatment-hope/. Accessed 6 september 2026.
nathaniel bowman. Micrornas drive liver cancer regulation and offer new treatment hope. Scienmag. September 6, 2026. Https://scienmag.Com/micrornas-drive-liver-cancer-regulation-and-offer-new-treatment-hope/ |
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| South Carolina Had Kent State Coach Playing Scared From The Start |
| Posted on Sunday, September 06 @ 00:01:53 PDT (2 reads) | |
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Kent state coach mark carney didn’t sugarcoat it after saturday’s 57-0 season-opening loss to south carolina. He pointed to a handful of problem areas, starting with the way his offense handled second down and continuing through a game that never gave the golden flashes much room to breathe.
“obviously, it was a disappointing loss. South carolina is a really, good football team.
you know, are they 57 points better than us? That is my question,” carney said.
“i thought offensively, second down was our bugaboo. I thought we were efficient on first down.
we did some good things on third down, but second down wasn’t our best down.”
kent state finished just 4 of 10 on third down, including 1 of 4 in the second half. Carney said the inability to stay on schedule hurt the offense throughout the afternoon.
the conditions only made things tougher. Saturday’s matchup was the hottest game ever played at williams-brice stadium, with the temperature at 95 degrees at kickoff and climbing to 99 in the second half. The heat index reached 111 degrees, and the teams agreed to shorten the fourth quarter to 10 minutes so the game could be finished more quickly.
the previous high at the stadium was 94 degrees against old dominion in 2024. For kent state, which is based in northeast ohio, the weather was a major adjustment.
“we felt it,” carney said of the temperature. “The weather in any game is a great equalizer.
it’s hard to simulate this kind of environment in practice. I thought our guys did well coming into the week hydrating.
we lost a couple guys there in the second half to some cramps, but i thought we were ready for it.”
there was also a sequence in the second quarter that briefly looked like a turning point. With south carolina leading 15-0, quarterback lanorris sellers connected with dj black for a 16-yard gain to the gamecocks’ 23-yard line, but black fumbled on the play. It appeared kent state might come away with the ball after the scramble, though officials ruled black had recovered it at the 24.
“they said they blew it dead,” carney said when asked what he was told after the play.
carney also said he was more cautious than he might normally be on fourth down because of south carolina’s edge up front. Kent state never went for it on fourth down and chose to punt each time.
“probably have been a little bit more aggressive in those situations. I think we had three fourth-and-1s near midfield in the first half,” carney said.
“if i didn’t feel the mismatch in the trenches, i would have probably would have been a little bit more aggressive in those situations. We weren’t good enough as far as staying on the field and executing.
and i think south carolina did a great job of that.”
in other news...
south carolinas home opener is creating a columbia traffic headache
south carolinas 2026 home opener against kent state arrives with more than just the usual first-game buzz in columbia. With a 12:45 p.M. Kickoff at williams-brice stadium and the date landing on labor day weekend, the game is expected to draw the kind of early crowd that can clog roads well before fans reach their seats.
officials are already warning that traffic patterns around the stadium will be adjusted, and they are urging fans to plan ahead by buying parking in advance and using shuttles when possible. For anyone not headed to the game, the safest move may be steering clear of the stadium area altogether, because this one figures to test the citys patience before the gamecocks even take the field. [Read more ????]
south carolina lost a gamecock figure who shaped far more than football
joe rices influence around the university of south carolina reached well beyond the football program, even if his name became familiar to gamecock fans through the athletic facilities that bear it. The prominent alumnus and donor died unexpectedly on sept. 3 at age 72, leaving behind a long record of support that helped shape both the universitys academic profile and its athletics footprint.
rices gifts helped name the joseph f. Rice school of law and the rice athletic center, and he also backed scholarships for law students, underscoring how broadly his impact was felt across campus. The university plans to honor him ahead of the gamecock football season opener on sept. 5, a fitting reminder that some figures leave a mark that stretches far beyond the field. [Read more ????]
beamer knows south carolinas bigger problem starts after halftime
shane beamer has been quick to point out that south carolinas first-half play has often put the gamecocks in position to win, but hes also been honest about how little that matters once the second half begins. The coach said the team has generally handled games well when it leads or is tied at halftime, yet recent losses after entering the break in front have made the lesson harder to ignore. For south carolina, the early script has usually been good enough to create hope.
beamer stressed that efficient football before halftime still matters, but he pushed back on the idea that the entire game plan should revolve around reaching the break with a lead. In his view, a halftime edge is nice to have, not the finish line, and the gamecocks have learned the hard way that the real work starts after the locker room doors open again. The challenge now is turning those solid starts into complete games. [Read more ????] |
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| Volleyball sweeps Dean, Southern Maine to close out Maine Coast Classic |
| Posted on Sunday, September 06 @ 00:01:53 PDT (2 reads) | |
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Meriden photography studio 0 dean dean 0-3 3 winner maine maritime maine ma 1-1 dean dean 0-3 0 final sep. 05, 2026 3 maine maritime maine ma 1-1 winner set scores team 1 2 3 f dean dean 11 7 9 (0) maine maritime maine ma 25 25 25 (3) 3 winner maine maritime maine ma 2-1 0 southern me. Southern 1-3 winner maine maritime maine ma 2-1 3 final sep. 05, 2026 0 southern me. Southern 1-3 set scores team 1 2 3 f maine maritime maine ma 25 25 25 (3) southern me. Southern 12 22 15 (0) next match: vs. University of scranton 9/11/2026 | 6 p.M. Next match full schedule sep. 11 (fri) / 6 p.M. Vs. University of scranton history roster game recap: womens volleyball | 9/5/2026 8:06:00 pm volleyball sweeps dean, southern maine to close out maine coast classic gorham, maine — the maine maritime academy volleyball team picked up a pair of convincing victories saturday at hill gym, sweeping dean college and the university of southern maine to improve to 2-1 on the season. The mariners opened the day with a dominant 3-0 victory over dean, winning 25-11, 25-7, 25-9, before completing the sweep of southern maine, 25-12, 25-22, 25-15. Maine maritime controlled the match against dean from the opening serve, jumping out to a 10-3 lead in the first set before cruising to a 25-11 victory. The mariners carried that momentum into the second set, opening with a 6-0 run and building a 17-4 advantage before taking the set 25-7. Maine maritime closed out the match with another strong start in the third set and finished with a 25-9 victory. Senior ally hadley led the mariners with 11 kills on 18 attacks while hitting .444. Senior sydney williams added six kills on 13 attacks with a .462 hitting percentage, while freshman lyla annen recorded four kills. Freshmen kelsie murray and jaslene butler each contributed three kills. Freshman faith reed orchestrated the offense with 21 assists and added six service aces. Junior hannah tate contributed five assists and a team-high 15 digs, while williams and annen each recorded eight digs. The mariners finished the dean match with 30 kills against just five errors for a .362 team hitting percentage. Maine maritime also recorded 14 service aces and three team blocks. Maine maritime carried that momentum into its second match of the day against southern maine, earning another three-set victory. The mariners took the opening set 25-12 after building a 16-7 lead and closing on a 9-5 run. The second set featured a much tighter battle, with the teams tied at 14-14 before maine maritime used a 5-0 run to take a 19-15 lead. Southern maine pulled within one at 19-18, but the mariners answered and finished the set 25-22. Maine maritime again took control early in the third set, turning a 2-2 tie into a 7-2 lead. The mariners extended their advantage to 11-5 and later used another 5-0 run to take a 17-10 lead before closing out the match, 25-15. Annen and hadley led the mariners with 11 kills apiece against southern maine, while williams added 10 kills. Hadley finished with a team-high 14 points and eight digs, while williams recorded 14 points, three digs and two blocks. Reed directed the offense with 28 assists and added 12 digs. Tate contributed six assists and a team-high 18 digs, while annen also recorded 12 digs. Maine maritime finished the southern maine match with 40 kills, eight service aces and four blocks while hitting .182 as a team. The mariners collected 55 digs in the three-set victory. The mariners return to action on friday at the mit invitational with a matchup against the university of scranton at 6 p.M. Print friendly version players mentioned #7 ally hadley oh 5 8 senior #6 hannah tate l/ds 5 5 junior #9 sydney williams oh 6 0 senior #13 lyla annen oh 5 7 freshman #18 jaslene butler mh 5 7 freshman #20 kelsie murray mh 6 0 freshman #21 faith reed s 5 4 freshman players mentioned #7 ally hadley 5 8 senior oh #6 hannah tate 5 5 junior l/ds #9 sydney williams 6 0 senior oh #13 lyla annen 5 7 freshman oh #18 jaslene butler 5 7 freshman mh #20 kelsie murray 6 0 freshman mh #21 faith reed 5 4 freshman s |
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| Football drops season opener on the road against Mass. Maritime |
| Posted on Sunday, September 06 @ 00:01:53 PDT (2 reads) | |
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Meriden photography studio box score 0 maine maritime mem 0-0 , 0-0 49 winner mass. Maritime mma 0-0 , 0-0 maine maritime mem 0-0 , 0-0 0 final sep. 05, 2026 49 mass. Maritime mma 0-0 , 0-0 winner score by quarters team 1st 2nd 3rd 4th f mem maine maritime 0 0 0 0 0 mma mass. Maritime 3 20 19 7 49 next game: at vermont state university castleton 9/19/2026 | noon next game full schedule sep. 19 (sat) / noon at vermont state university castleton history roster game recap: football | 9/5/2026 7:55:00 pm football drops season opener on the road against mass. Maritime bourne, mass. — The maine maritime academy football team fell to massachusetts maritime academy, 49-0, in its 2026 season opener saturday afternoon at clean harbors stadium. The mariners were held to 111 yards of total offense, including 79 rushing yards and 32 passing yards. Maine maritime recorded seven first downs and converted 2 of 9 third-down opportunities. Junior auston harris led the mariners on the ground, carrying 18 times for 84 yards, averaging 4.7 yards per carry with a long of 13 yards. Harris also added two receptions for two yards. Sophomore quarterback harris stone completed 7 of 19 passes for 32 yards while also rushing four times for minus-5 yards. Senior ty regis led maine maritime with two receptions for 14 yards, while freshman evan flowers caught two passes for 11 yards. Sophomore eli bennett added one reception for five yards. Flowers provided a spark in the return game, totaling 111 yards on five kickoff returns, including a 35-yard return, while adding an 11-yard punt return. Defensively, junior lucas houghton led the mariners with 10 total tackles, including six solo stops and four assists. Junior matt gagin and sophomore liam sullivan each finished with nine tackles, while junior james boyer-russell recorded eight tackles and a team-high 1.5 tackles for loss along with a sack. The mariners will get a week off before traveling to face vermont state university castleton on sept. 19 with kickoff set for noon. Print friendly version players mentioned #12 eli bennett wr 5 11 sophomore #1 james boyer-russell db 6 1 junior #5 matt gagin lb 5 9 junior #4 auston harris rb 5 10 junior #0 lucas houghton db 6 1 junior #2 ty regis wr 6 0 senior #56 liam sullivan dl 6 1 sophomore players mentioned #12 eli bennett 5 11 sophomore wr #1 james boyer-russell 6 1 junior db #5 matt gagin 5 9 junior lb #4 auston harris 5 10 junior rb #0 lucas houghton 6 1 junior db #2 ty regis 6 0 senior wr #56 liam sullivan 6 1 sophomore dl |
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| PPF calls on youth to join Africas reparations fight - Memesita |
| Posted on Sunday, September 06 @ 00:01:53 PDT (2 reads) | |
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The pan-african progressive front (ppf), a continental solidarity movement, convened a youth forum at the university of ghana on september 5, 2026, to mobilize young africans against colonial debt and demand reparations. The event, titled africa’s freedom is in our hands: reclaiming africa’s wealth, resisting neocolonial bondage, was held at the isser conference hall in legon. The forum sought to shift the reparations movement from policy circles into active, youth-led resistance, bringing together ghanaian youth, students from mali, burkina faso and niger, foreign students, scholars, diplomats, and policymakers.
mobilizing youth for economic sovereignty
organizers framed the gathering as a necessary evolution in the pan-african struggle, moving beyond the historical focus on political independence toward the urgent need for economic autonomy. Humphrey abbey quaye, coordinator of the pan-african progressive front, argued that africa’s current debt burden is not a consequence of poor management, but a legacy of centuries of slavery, colonial exploitation, and continuing neocolonial control. He emphasized that the continent is effectively paying interest on wealth that was historically extracted through the removal of african labour, knowledge, land, and mineral resources.
the so-called debt crisis of africa is not an accident, neither is it an african creation,
mr. Quaye told attendees, describing it as a continuation of the exploitation associated with slavery, colonialism, neocolonialism, and imperialism. He insisted that any genuine reparations process must ultimately be based on justice, noting that it is impossible to discuss the debt crisis without addressing resetting, repair and restitution.
the role of the youth in reparations
theresa boateng, a youth representative for the ppf, urged participants to transition from observers to active participants in the struggle. She identified three specific actions for young people: studying true african history beyond mainstream distortions, joining progressive pan-african organizations, and mobilizing for concrete reparations action and economic justice across the continent. She specifically encouraged attendees to read books such as walter rodney’s how europe underdeveloped africa
to deepen their understanding of the continent’s history.
we do ask the question sometimes that after school, what are the chances or what are the prospects for us in terms of jobs, in terms of employment,
madam boateng said, describing the lack of prospects as a systemic problem linked to how the continent’s resources continued to be plundered. She noted that the current condition of ghana and its sister african countries did not occur in a vacuum, pointing to cultural artifacts held in foreign museums as physical evidence of the need for a restitution campaign. The reparations struggle is not going to be given on a silver platter. The institutions that bind us, that continue to keep us in immiseration, and indebtedness need to be recalibrated,
she said.
challenging the architecture of neocolonialism
the forum sessions addressed the broader architecture of control, specifically the cfa franc, which organizers described as a currency pegged to france and managed by the french treasury. The ppf rejects neocolonialism in all forms, including foreign military bases, overseas-controlled currencies, and partnerships established without local input. Organizers argued that the cfa is not merely a currency, but “a leash” backed by financial coercion and military interventions.
the event also drew on international momentum, specifically the march 25, 2025, un general assembly resolution. In that landmark vote, 123 nations supported ghana’s resolution to declare the trafficking of enslaved africans and racialised chattel enslavement as the gravest crime against humanity.
the resolution, which saw 52 abstentions and three votes against—the united states, israel, and argentina—affirmed that reparations serve as a concrete step toward remedy.
next steps for the pan-african movement
the ppf operates as a united front bringing together progressive political parties, trade unions, youth and women’s movements, peasant organizations, and socialist formations across africa, the caribbean, and the black diaspora. Having established its international headquarters in accra on june 30, 2025, the organization has spent the last 18 months building a common platform, including a virtual conference involving more than 60 pan-african formations from 32 countries.
participants at the accra forum engaged in three main sessions: youth role in reparations: what can youth do?
, reparations flashmob and micro lawsuits,
and debt cancellation and the global debt trap.
the movement maintains that reparations are not a charitable gesture to be requested, but a debt owed for centuries of extracted resources, labor, and dignity. Furthermore, the ppf rejects the legitimacy of debts incurred by colonial administrations or imposed by the imf, arguing they were contracted under duress without popular consent and carry no moral or legal weight. |
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