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| Remembering film critic and News Hour regular Ann Hornaday |
| Posted on Tuesday, October 20 @ 00:00:19 PDT (13 reads) | |
|
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pbs news hour
remembering film critic and news hour regular ann hornaday
bruce springsteen: finding america in song
bruce springsteen: finding america in song
bruce springsteen: finding america in song
bruce springsteen: finding america in song
bruce springsteen: finding america in song
bruce springsteen: finding america in song
president trump address to the nation — pbs news special report
president trump address to the nation — pbs news special report
president trump address to the nation — pbs news special report
war with iran | pbs news special report
war with iran | pbs news special report
war with iran | pbs news special report
president donald trump’s 2026 state of the union address
president donald trump’s 2026 state of the union address
president donald trump’s 2026 state of the union address
trump addresses the nation from the white house
trump addresses the nation from the white house
trump addresses the nation from the white house
president donald trumps 2025 address to congress
president donald trump on march 4, 2025, will address a joint session of congress.
president donald trump on march 4, 2025, will address a joint session of congress.
harris addresses supporters after losing 2024 presidential election
harris addresses supporters after losing 2024 presidential election
harris addresses supporters after losing 2024 presidential election
beyond the canvas | season 2 | episode 3
women of wonder
women of wonder
2020 final presidential debate
president donald trump and former vice president joe biden meet in the final debate.
president donald trump and former vice president joe biden meet in the final debate.
the trump impeachment trial - day 1
the trump impeachment trial - day 1
the trump impeachment trial - day 1
pbs newshour/politico democratic debate
the pbs newshour and politico are hosting the sixth democratic debate on dec. 1, 2019.
the pbs newshour and politico are hosting the sixth democratic debate on dec. 1, 2019.
pbs newshour iowa caucus special
pbs newshour iowa caucus special
pbs newshour iowa caucus special
beyond the canvas | season 2 | episode 1
finding one’s voice as a writer takes dedication, courage, and a willingness to reimagine the world through words on a page. In this episode of “beyond the canvas,” we sit down with novelist margaret atwood, playwright danai gurira, and others to talk about finding meaning as a writer.
finding one’s voice as a writer takes dedication, courage, and a willingness to reimagine the world through words on a page. In this episode of “beyond the canvas,” we sit down with novelist margaret atwood, playwright danai gurira, and others to talk about finding meaning as a writer.
pbs newshour new hampshire primary special
pbs newshour new hampshire primary special
pbs newshour new hampshire primary special
pbs newshour march 10th primary special coverage
pbs newshour march 10th primary special coverage
pbs newshour march 10th primary special coverage
celebrating america - a pbs newshour inauguration special
celebrating america - a pbs newshour inauguration special
celebrating america - a pbs newshour inauguration special
invisible scars | part 2
breaking the cycle of childhood trauma in rural montana
breaking the cycle of childhood trauma in rural montana
pbs newshour 2020 election update special
pbs newshour discusses this historic election and what comes next.
pbs newshour discusses this historic election and what comes next.
republican national convention - day 2
coverage of the republican national convention - day 2
coverage of the republican national convention - day 2
invisible scars | part 1
childhood trauma impacts millions of americans, and it’s having devastating consequences
childhood trauma impacts millions of americans, and it’s having devastating consequences
republican national convention - day 1
coverage of the republican national convention - day 1
coverage of the republican national convention - day 1
race matters: america after george floyd
one year after police killed george floyd, where does america go from here?
one year after police killed george floyd, where does america go from here?
witness to the siege - a pbs newshour special
witness to the siege - a pbs newshour special
witness to the siege - a pbs newshour special
president joe biden’s first joint address to congress
president joe biden will address a joint session of congress for the first time.
president joe biden will address a joint session of congress for the first time.
america in black and blue 2020: pbs newshour weekend special
pbs newshour weekend’s “america in black and blue 2020” - a special on race and policing.
pbs newshour weekend’s “america in black and blue 2020” - a special on race and policing.
pbs newshour/npr rnc special – day 4
pbs newshour/npr republican national convention special – day 4
pbs newshour/npr republican national convention special – day 4
the trump impeachment hearings - day 3
the trump impeachment hearings - day 3
the trump impeachment hearings - day 3
watch: 2020 vice presidential debate
vice president mike pence meets sen. Kamala harris in the vice presidential debate.
vice president mike pence meets sen. Kamala harris in the vice presidential debate.
the trump impeachment hearings - day 1
the trump impeachment hearings - day 1
the trump impeachment hearings - day 1
republican national convention: august 29, 2012 (part 2)
republican national convention: august 29, 2012 (part 2)
republican national convention: august 29, 2012 (part 2)
republican national convention: august 29, 2012 (part 1)
republican national convention: august 29, 2012 (part 1)
republican national convention: august 29, 2012 (part 1)
special report: america remembers 9/11
special report: america remembers 9/11
special report: america remembers 9/11
pbs newshour full state of the union special jan. 20, 2015
pbs newshour state of the union 2015 special report.
pbs newshour state of the union 2015 special report.
pbs newshour 2013 state of the union special report
pbs newshour 2013 state of the union special report
pbs newshour 2013 state of the union special report
watch the full 2012 vice presidential debate
watch the full pbs newshour 2012 vice presidential debate special
watch the full pbs newshour 2012 vice presidential debate special
democratic national convention: september 5, 2012 (part 2)
democratic national convention: september 5, 2012 (part 2)
democratic national convention: september 5, 2012 (part 2)
democratic national convention: september 6, 2012
democratic national convention: september 6, 2012
democratic national convention: september 6, 2012
democratic national convention: september 5, 2012 (part 1)
democratic national convention: september 5, 2012 (part 1)
democratic national convention: september 5, 2012 (part 1)
democratic national convention: september 4, 2012 (part 1)
democratic national convention: september 4, 2012
democratic national convention: september 4, 2012
democratic national convention: september 4, 2012 (part 2)
democratic national convention: september 4, 2012 (part 2)
democratic national convention: september 4, 2012 (part 2)
pbs newshour/npr - dnc special - day 1
pbs newshour/npr democratic national convention special - day 1
pbs newshour/npr democratic national convention special - day 1
pbs newshour/npr dnc special - day 2
pbs newshour/npr democratic national convention special - day 2
pbs newshour/npr democratic national convention special - day 2
pbs newshour/npr rnc special - day 3
pbs newshour/npr republican national convention special - day 3
pbs newshour/npr republican national convention special - day 3
pbs newshour/npr rnc special - day 3
pbs newshour/npr republican national convention special - day 3
pbs newshour/npr republican national convention special - day 3
pbs newshour/npr rnc special - day 2
watch tuesday nights pbs newshour/npr special from day 2 of the rnc in cleveland.
watch tuesday nights pbs newshour/npr special from day 2 of the rnc in cleveland.
pbs newshour/npr rnc special - day 1
pbs newshour/npr republican national convention special – day 1
pbs newshour/npr republican national convention special – day 1
searching for justice | part 3
changing the criminal justice system on behalf of children
changing the criminal justice system on behalf of children
democratic national convention - day 2
coverage of the democratic national convention - day 2
coverage of the democratic national convention - day 2
the trump impeachment hearings - day 2
the trump impeachment hearings - day 2
the trump impeachment hearings - day 2
democratic national convention - day 3
coverage of the democratic national convention - day 3
coverage of the democratic national convention - day 3
impeachment trial of donald trump - day 12
watch the final vote in the trump impeachment trial.
watch the final vote in the trump impeachment trial.
the trump impeachment hearings - day 4
the trump impeachment hearings - day 4
the trump impeachment hearings - day 4
searching for justice | part 4
how drug testing in alabama holds former prisoners back from creating a new life
how drug testing in alabama holds former prisoners back from creating a new life
searching for justice | part 1
free from prison after 23 years, but facing new challenges during the pandemic
free from prison after 23 years, but facing new challenges during the pandemic
watch: biden speaks after electoral college vote
watch live: biden speaks after electoral college certification results
watch live: biden speaks after electoral college certification results
searching for justice | part 2
the vicious cycle of incarceration and homelessness
the vicious cycle of incarceration and homelessness
pbs newshour/npr dnc special - day 3
pbs newshour/npr democratic national convention special - day 3
pbs newshour/npr democratic national convention special - day 3
questions for president obama: a town hall special
president barack obama joins gwen ifill for a town hall conversation in elkhart, indiana.
president barack obama joins gwen ifill for a town hall conversation in elkhart, indiana.
watch the full first presidential debate
hillary clinton and donald trump faced off for the first debate at hofstra university.
hillary clinton and donald trump faced off for the first debate at hofstra university. |
( Read More... | 20744 bytes more | comments? |   ) |
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| News Wrap: Judge clashes with DOJ over D.C. golf course |
| Posted on Tuesday, October 20 @ 00:00:19 PDT (13 reads) | |
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pbs news hour
news wrap: judge clashes with doj over d.C. Golf course
bruce springsteen: finding america in song
bruce springsteen: finding america in song
bruce springsteen: finding america in song
bruce springsteen: finding america in song
bruce springsteen: finding america in song
bruce springsteen: finding america in song
president trump address to the nation — pbs news special report
president trump address to the nation — pbs news special report
president trump address to the nation — pbs news special report
war with iran | pbs news special report
war with iran | pbs news special report
war with iran | pbs news special report
president donald trump’s 2026 state of the union address
president donald trump’s 2026 state of the union address
president donald trump’s 2026 state of the union address
trump addresses the nation from the white house
trump addresses the nation from the white house
trump addresses the nation from the white house
president donald trumps 2025 address to congress
president donald trump on march 4, 2025, will address a joint session of congress.
president donald trump on march 4, 2025, will address a joint session of congress.
harris addresses supporters after losing 2024 presidential election
harris addresses supporters after losing 2024 presidential election
harris addresses supporters after losing 2024 presidential election
beyond the canvas | season 2 | episode 3
women of wonder
women of wonder
2020 final presidential debate
president donald trump and former vice president joe biden meet in the final debate.
president donald trump and former vice president joe biden meet in the final debate.
the trump impeachment trial - day 1
the trump impeachment trial - day 1
the trump impeachment trial - day 1
pbs newshour/politico democratic debate
the pbs newshour and politico are hosting the sixth democratic debate on dec. 1, 2019.
the pbs newshour and politico are hosting the sixth democratic debate on dec. 1, 2019.
pbs newshour iowa caucus special
pbs newshour iowa caucus special
pbs newshour iowa caucus special
beyond the canvas | season 2 | episode 1
finding one’s voice as a writer takes dedication, courage, and a willingness to reimagine the world through words on a page. In this episode of “beyond the canvas,” we sit down with novelist margaret atwood, playwright danai gurira, and others to talk about finding meaning as a writer.
finding one’s voice as a writer takes dedication, courage, and a willingness to reimagine the world through words on a page. In this episode of “beyond the canvas,” we sit down with novelist margaret atwood, playwright danai gurira, and others to talk about finding meaning as a writer.
pbs newshour new hampshire primary special
pbs newshour new hampshire primary special
pbs newshour new hampshire primary special
pbs newshour march 10th primary special coverage
pbs newshour march 10th primary special coverage
pbs newshour march 10th primary special coverage
celebrating america - a pbs newshour inauguration special
celebrating america - a pbs newshour inauguration special
celebrating america - a pbs newshour inauguration special
invisible scars | part 2
breaking the cycle of childhood trauma in rural montana
breaking the cycle of childhood trauma in rural montana
pbs newshour 2020 election update special
pbs newshour discusses this historic election and what comes next.
pbs newshour discusses this historic election and what comes next.
republican national convention - day 2
coverage of the republican national convention - day 2
coverage of the republican national convention - day 2
invisible scars | part 1
childhood trauma impacts millions of americans, and it’s having devastating consequences
childhood trauma impacts millions of americans, and it’s having devastating consequences
republican national convention - day 1
coverage of the republican national convention - day 1
coverage of the republican national convention - day 1
race matters: america after george floyd
one year after police killed george floyd, where does america go from here?
one year after police killed george floyd, where does america go from here?
witness to the siege - a pbs newshour special
witness to the siege - a pbs newshour special
witness to the siege - a pbs newshour special
president joe biden’s first joint address to congress
president joe biden will address a joint session of congress for the first time.
president joe biden will address a joint session of congress for the first time.
america in black and blue 2020: pbs newshour weekend special
pbs newshour weekend’s “america in black and blue 2020” - a special on race and policing.
pbs newshour weekend’s “america in black and blue 2020” - a special on race and policing.
pbs newshour/npr rnc special – day 4
pbs newshour/npr republican national convention special – day 4
pbs newshour/npr republican national convention special – day 4
the trump impeachment hearings - day 3
the trump impeachment hearings - day 3
the trump impeachment hearings - day 3
watch: 2020 vice presidential debate
vice president mike pence meets sen. Kamala harris in the vice presidential debate.
vice president mike pence meets sen. Kamala harris in the vice presidential debate.
the trump impeachment hearings - day 1
the trump impeachment hearings - day 1
the trump impeachment hearings - day 1
republican national convention: august 29, 2012 (part 2)
republican national convention: august 29, 2012 (part 2)
republican national convention: august 29, 2012 (part 2)
republican national convention: august 29, 2012 (part 1)
republican national convention: august 29, 2012 (part 1)
republican national convention: august 29, 2012 (part 1)
special report: america remembers 9/11
special report: america remembers 9/11
special report: america remembers 9/11
pbs newshour full state of the union special jan. 20, 2015
pbs newshour state of the union 2015 special report.
pbs newshour state of the union 2015 special report.
pbs newshour 2013 state of the union special report
pbs newshour 2013 state of the union special report
pbs newshour 2013 state of the union special report
watch the full 2012 vice presidential debate
watch the full pbs newshour 2012 vice presidential debate special
watch the full pbs newshour 2012 vice presidential debate special
democratic national convention: september 5, 2012 (part 2)
democratic national convention: september 5, 2012 (part 2)
democratic national convention: september 5, 2012 (part 2)
democratic national convention: september 6, 2012
democratic national convention: september 6, 2012
democratic national convention: september 6, 2012
democratic national convention: september 5, 2012 (part 1)
democratic national convention: september 5, 2012 (part 1)
democratic national convention: september 5, 2012 (part 1)
democratic national convention: september 4, 2012 (part 1)
democratic national convention: september 4, 2012
democratic national convention: september 4, 2012
democratic national convention: september 4, 2012 (part 2)
democratic national convention: september 4, 2012 (part 2)
democratic national convention: september 4, 2012 (part 2)
pbs newshour/npr - dnc special - day 1
pbs newshour/npr democratic national convention special - day 1
pbs newshour/npr democratic national convention special - day 1
pbs newshour/npr dnc special - day 2
pbs newshour/npr democratic national convention special - day 2
pbs newshour/npr democratic national convention special - day 2
pbs newshour/npr rnc special - day 3
pbs newshour/npr republican national convention special - day 3
pbs newshour/npr republican national convention special - day 3
pbs newshour/npr rnc special - day 3
pbs newshour/npr republican national convention special - day 3
pbs newshour/npr republican national convention special - day 3
pbs newshour/npr rnc special - day 2
watch tuesday nights pbs newshour/npr special from day 2 of the rnc in cleveland.
watch tuesday nights pbs newshour/npr special from day 2 of the rnc in cleveland.
pbs newshour/npr rnc special - day 1
pbs newshour/npr republican national convention special – day 1
pbs newshour/npr republican national convention special – day 1
searching for justice | part 3
changing the criminal justice system on behalf of children
changing the criminal justice system on behalf of children
democratic national convention - day 2
coverage of the democratic national convention - day 2
coverage of the democratic national convention - day 2
the trump impeachment hearings - day 2
the trump impeachment hearings - day 2
the trump impeachment hearings - day 2
democratic national convention - day 3
coverage of the democratic national convention - day 3
coverage of the democratic national convention - day 3
impeachment trial of donald trump - day 12
watch the final vote in the trump impeachment trial.
watch the final vote in the trump impeachment trial.
the trump impeachment hearings - day 4
the trump impeachment hearings - day 4
the trump impeachment hearings - day 4
searching for justice | part 4
how drug testing in alabama holds former prisoners back from creating a new life
how drug testing in alabama holds former prisoners back from creating a new life
searching for justice | part 1
free from prison after 23 years, but facing new challenges during the pandemic
free from prison after 23 years, but facing new challenges during the pandemic
watch: biden speaks after electoral college vote
watch live: biden speaks after electoral college certification results
watch live: biden speaks after electoral college certification results
searching for justice | part 2
the vicious cycle of incarceration and homelessness
the vicious cycle of incarceration and homelessness
pbs newshour/npr dnc special - day 3
pbs newshour/npr democratic national convention special - day 3
pbs newshour/npr democratic national convention special - day 3
questions for president obama: a town hall special
president barack obama joins gwen ifill for a town hall conversation in elkhart, indiana.
president barack obama joins gwen ifill for a town hall conversation in elkhart, indiana.
watch the full first presidential debate
hillary clinton and donald trump faced off for the first debate at hofstra university.
hillary clinton and donald trump faced off for the first debate at hofstra university. |
| ( Read More... | 20738 bytes more | comments? | ) |
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| Trump escalates Zelenskyy feud as Russia continues attacks |
| Posted on Tuesday, October 20 @ 00:00:19 PDT (14 reads) | |
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pbs news hour
trump escalates zelenskyy feud as russia continues attacks
bruce springsteen: finding america in song
bruce springsteen: finding america in song
bruce springsteen: finding america in song
bruce springsteen: finding america in song
bruce springsteen: finding america in song
bruce springsteen: finding america in song
president trump address to the nation — pbs news special report
president trump address to the nation — pbs news special report
president trump address to the nation — pbs news special report
war with iran | pbs news special report
war with iran | pbs news special report
war with iran | pbs news special report
president donald trump’s 2026 state of the union address
president donald trump’s 2026 state of the union address
president donald trump’s 2026 state of the union address
trump addresses the nation from the white house
trump addresses the nation from the white house
trump addresses the nation from the white house
president donald trumps 2025 address to congress
president donald trump on march 4, 2025, will address a joint session of congress.
president donald trump on march 4, 2025, will address a joint session of congress.
harris addresses supporters after losing 2024 presidential election
harris addresses supporters after losing 2024 presidential election
harris addresses supporters after losing 2024 presidential election
beyond the canvas | season 2 | episode 3
women of wonder
women of wonder
2020 final presidential debate
president donald trump and former vice president joe biden meet in the final debate.
president donald trump and former vice president joe biden meet in the final debate.
the trump impeachment trial - day 1
the trump impeachment trial - day 1
the trump impeachment trial - day 1
pbs newshour/politico democratic debate
the pbs newshour and politico are hosting the sixth democratic debate on dec. 1, 2019.
the pbs newshour and politico are hosting the sixth democratic debate on dec. 1, 2019.
pbs newshour iowa caucus special
pbs newshour iowa caucus special
pbs newshour iowa caucus special
beyond the canvas | season 2 | episode 1
finding one’s voice as a writer takes dedication, courage, and a willingness to reimagine the world through words on a page. In this episode of “beyond the canvas,” we sit down with novelist margaret atwood, playwright danai gurira, and others to talk about finding meaning as a writer.
finding one’s voice as a writer takes dedication, courage, and a willingness to reimagine the world through words on a page. In this episode of “beyond the canvas,” we sit down with novelist margaret atwood, playwright danai gurira, and others to talk about finding meaning as a writer.
pbs newshour new hampshire primary special
pbs newshour new hampshire primary special
pbs newshour new hampshire primary special
pbs newshour march 10th primary special coverage
pbs newshour march 10th primary special coverage
pbs newshour march 10th primary special coverage
celebrating america - a pbs newshour inauguration special
celebrating america - a pbs newshour inauguration special
celebrating america - a pbs newshour inauguration special
invisible scars | part 2
breaking the cycle of childhood trauma in rural montana
breaking the cycle of childhood trauma in rural montana
pbs newshour 2020 election update special
pbs newshour discusses this historic election and what comes next.
pbs newshour discusses this historic election and what comes next.
republican national convention - day 2
coverage of the republican national convention - day 2
coverage of the republican national convention - day 2
invisible scars | part 1
childhood trauma impacts millions of americans, and it’s having devastating consequences
childhood trauma impacts millions of americans, and it’s having devastating consequences
republican national convention - day 1
coverage of the republican national convention - day 1
coverage of the republican national convention - day 1
race matters: america after george floyd
one year after police killed george floyd, where does america go from here?
one year after police killed george floyd, where does america go from here?
witness to the siege - a pbs newshour special
witness to the siege - a pbs newshour special
witness to the siege - a pbs newshour special
president joe biden’s first joint address to congress
president joe biden will address a joint session of congress for the first time.
president joe biden will address a joint session of congress for the first time.
america in black and blue 2020: pbs newshour weekend special
pbs newshour weekend’s “america in black and blue 2020” - a special on race and policing.
pbs newshour weekend’s “america in black and blue 2020” - a special on race and policing.
pbs newshour/npr rnc special – day 4
pbs newshour/npr republican national convention special – day 4
pbs newshour/npr republican national convention special – day 4
the trump impeachment hearings - day 3
the trump impeachment hearings - day 3
the trump impeachment hearings - day 3
watch: 2020 vice presidential debate
vice president mike pence meets sen. Kamala harris in the vice presidential debate.
vice president mike pence meets sen. Kamala harris in the vice presidential debate.
the trump impeachment hearings - day 1
the trump impeachment hearings - day 1
the trump impeachment hearings - day 1
republican national convention: august 29, 2012 (part 2)
republican national convention: august 29, 2012 (part 2)
republican national convention: august 29, 2012 (part 2)
republican national convention: august 29, 2012 (part 1)
republican national convention: august 29, 2012 (part 1)
republican national convention: august 29, 2012 (part 1)
special report: america remembers 9/11
special report: america remembers 9/11
special report: america remembers 9/11
pbs newshour full state of the union special jan. 20, 2015
pbs newshour state of the union 2015 special report.
pbs newshour state of the union 2015 special report.
pbs newshour 2013 state of the union special report
pbs newshour 2013 state of the union special report
pbs newshour 2013 state of the union special report
watch the full 2012 vice presidential debate
watch the full pbs newshour 2012 vice presidential debate special
watch the full pbs newshour 2012 vice presidential debate special
democratic national convention: september 5, 2012 (part 2)
democratic national convention: september 5, 2012 (part 2)
democratic national convention: september 5, 2012 (part 2)
democratic national convention: september 6, 2012
democratic national convention: september 6, 2012
democratic national convention: september 6, 2012
democratic national convention: september 5, 2012 (part 1)
democratic national convention: september 5, 2012 (part 1)
democratic national convention: september 5, 2012 (part 1)
democratic national convention: september 4, 2012 (part 1)
democratic national convention: september 4, 2012
democratic national convention: september 4, 2012
democratic national convention: september 4, 2012 (part 2)
democratic national convention: september 4, 2012 (part 2)
democratic national convention: september 4, 2012 (part 2)
pbs newshour/npr - dnc special - day 1
pbs newshour/npr democratic national convention special - day 1
pbs newshour/npr democratic national convention special - day 1
pbs newshour/npr dnc special - day 2
pbs newshour/npr democratic national convention special - day 2
pbs newshour/npr democratic national convention special - day 2
pbs newshour/npr rnc special - day 3
pbs newshour/npr republican national convention special - day 3
pbs newshour/npr republican national convention special - day 3
pbs newshour/npr rnc special - day 3
pbs newshour/npr republican national convention special - day 3
pbs newshour/npr republican national convention special - day 3
pbs newshour/npr rnc special - day 2
watch tuesday nights pbs newshour/npr special from day 2 of the rnc in cleveland.
watch tuesday nights pbs newshour/npr special from day 2 of the rnc in cleveland.
pbs newshour/npr rnc special - day 1
pbs newshour/npr republican national convention special – day 1
pbs newshour/npr republican national convention special – day 1
searching for justice | part 3
changing the criminal justice system on behalf of children
changing the criminal justice system on behalf of children
democratic national convention - day 2
coverage of the democratic national convention - day 2
coverage of the democratic national convention - day 2
the trump impeachment hearings - day 2
the trump impeachment hearings - day 2
the trump impeachment hearings - day 2
democratic national convention - day 3
coverage of the democratic national convention - day 3
coverage of the democratic national convention - day 3
impeachment trial of donald trump - day 12
watch the final vote in the trump impeachment trial.
watch the final vote in the trump impeachment trial.
the trump impeachment hearings - day 4
the trump impeachment hearings - day 4
the trump impeachment hearings - day 4
searching for justice | part 4
how drug testing in alabama holds former prisoners back from creating a new life
how drug testing in alabama holds former prisoners back from creating a new life
searching for justice | part 1
free from prison after 23 years, but facing new challenges during the pandemic
free from prison after 23 years, but facing new challenges during the pandemic
watch: biden speaks after electoral college vote
watch live: biden speaks after electoral college certification results
watch live: biden speaks after electoral college certification results
searching for justice | part 2
the vicious cycle of incarceration and homelessness
the vicious cycle of incarceration and homelessness
pbs newshour/npr dnc special - day 3
pbs newshour/npr democratic national convention special - day 3
pbs newshour/npr democratic national convention special - day 3
questions for president obama: a town hall special
president barack obama joins gwen ifill for a town hall conversation in elkhart, indiana.
president barack obama joins gwen ifill for a town hall conversation in elkhart, indiana.
watch the full first presidential debate
hillary clinton and donald trump faced off for the first debate at hofstra university.
hillary clinton and donald trump faced off for the first debate at hofstra university. |
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| Kathryn Jezer-Morton joins Geoff Bennett on On Settle In |
| Posted on Tuesday, October 20 @ 00:00:19 PDT (12 reads) | |
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pbs news hour
kathryn jezer-morton joins geoff bennett on on settle in
bruce springsteen: finding america in song
bruce springsteen: finding america in song
bruce springsteen: finding america in song
bruce springsteen: finding america in song
bruce springsteen: finding america in song
bruce springsteen: finding america in song
president trump address to the nation — pbs news special report
president trump address to the nation — pbs news special report
president trump address to the nation — pbs news special report
war with iran | pbs news special report
war with iran | pbs news special report
war with iran | pbs news special report
president donald trump’s 2026 state of the union address
president donald trump’s 2026 state of the union address
president donald trump’s 2026 state of the union address
trump addresses the nation from the white house
trump addresses the nation from the white house
trump addresses the nation from the white house
president donald trumps 2025 address to congress
president donald trump on march 4, 2025, will address a joint session of congress.
president donald trump on march 4, 2025, will address a joint session of congress.
harris addresses supporters after losing 2024 presidential election
harris addresses supporters after losing 2024 presidential election
harris addresses supporters after losing 2024 presidential election
beyond the canvas | season 2 | episode 3
women of wonder
women of wonder
2020 final presidential debate
president donald trump and former vice president joe biden meet in the final debate.
president donald trump and former vice president joe biden meet in the final debate.
the trump impeachment trial - day 1
the trump impeachment trial - day 1
the trump impeachment trial - day 1
pbs newshour/politico democratic debate
the pbs newshour and politico are hosting the sixth democratic debate on dec. 1, 2019.
the pbs newshour and politico are hosting the sixth democratic debate on dec. 1, 2019.
pbs newshour iowa caucus special
pbs newshour iowa caucus special
pbs newshour iowa caucus special
beyond the canvas | season 2 | episode 1
finding one’s voice as a writer takes dedication, courage, and a willingness to reimagine the world through words on a page. In this episode of “beyond the canvas,” we sit down with novelist margaret atwood, playwright danai gurira, and others to talk about finding meaning as a writer.
finding one’s voice as a writer takes dedication, courage, and a willingness to reimagine the world through words on a page. In this episode of “beyond the canvas,” we sit down with novelist margaret atwood, playwright danai gurira, and others to talk about finding meaning as a writer.
pbs newshour new hampshire primary special
pbs newshour new hampshire primary special
pbs newshour new hampshire primary special
pbs newshour march 10th primary special coverage
pbs newshour march 10th primary special coverage
pbs newshour march 10th primary special coverage
celebrating america - a pbs newshour inauguration special
celebrating america - a pbs newshour inauguration special
celebrating america - a pbs newshour inauguration special
invisible scars | part 2
breaking the cycle of childhood trauma in rural montana
breaking the cycle of childhood trauma in rural montana
pbs newshour 2020 election update special
pbs newshour discusses this historic election and what comes next.
pbs newshour discusses this historic election and what comes next.
republican national convention - day 2
coverage of the republican national convention - day 2
coverage of the republican national convention - day 2
invisible scars | part 1
childhood trauma impacts millions of americans, and it’s having devastating consequences
childhood trauma impacts millions of americans, and it’s having devastating consequences
republican national convention - day 1
coverage of the republican national convention - day 1
coverage of the republican national convention - day 1
race matters: america after george floyd
one year after police killed george floyd, where does america go from here?
one year after police killed george floyd, where does america go from here?
witness to the siege - a pbs newshour special
witness to the siege - a pbs newshour special
witness to the siege - a pbs newshour special
president joe biden’s first joint address to congress
president joe biden will address a joint session of congress for the first time.
president joe biden will address a joint session of congress for the first time.
america in black and blue 2020: pbs newshour weekend special
pbs newshour weekend’s “america in black and blue 2020” - a special on race and policing.
pbs newshour weekend’s “america in black and blue 2020” - a special on race and policing.
pbs newshour/npr rnc special – day 4
pbs newshour/npr republican national convention special – day 4
pbs newshour/npr republican national convention special – day 4
the trump impeachment hearings - day 3
the trump impeachment hearings - day 3
the trump impeachment hearings - day 3
watch: 2020 vice presidential debate
vice president mike pence meets sen. Kamala harris in the vice presidential debate.
vice president mike pence meets sen. Kamala harris in the vice presidential debate.
the trump impeachment hearings - day 1
the trump impeachment hearings - day 1
the trump impeachment hearings - day 1
republican national convention: august 29, 2012 (part 2)
republican national convention: august 29, 2012 (part 2)
republican national convention: august 29, 2012 (part 2)
republican national convention: august 29, 2012 (part 1)
republican national convention: august 29, 2012 (part 1)
republican national convention: august 29, 2012 (part 1)
special report: america remembers 9/11
special report: america remembers 9/11
special report: america remembers 9/11
pbs newshour full state of the union special jan. 20, 2015
pbs newshour state of the union 2015 special report.
pbs newshour state of the union 2015 special report.
pbs newshour 2013 state of the union special report
pbs newshour 2013 state of the union special report
pbs newshour 2013 state of the union special report
watch the full 2012 vice presidential debate
watch the full pbs newshour 2012 vice presidential debate special
watch the full pbs newshour 2012 vice presidential debate special
democratic national convention: september 5, 2012 (part 2)
democratic national convention: september 5, 2012 (part 2)
democratic national convention: september 5, 2012 (part 2)
democratic national convention: september 6, 2012
democratic national convention: september 6, 2012
democratic national convention: september 6, 2012
democratic national convention: september 5, 2012 (part 1)
democratic national convention: september 5, 2012 (part 1)
democratic national convention: september 5, 2012 (part 1)
democratic national convention: september 4, 2012 (part 1)
democratic national convention: september 4, 2012
democratic national convention: september 4, 2012
democratic national convention: september 4, 2012 (part 2)
democratic national convention: september 4, 2012 (part 2)
democratic national convention: september 4, 2012 (part 2)
pbs newshour/npr - dnc special - day 1
pbs newshour/npr democratic national convention special - day 1
pbs newshour/npr democratic national convention special - day 1
pbs newshour/npr dnc special - day 2
pbs newshour/npr democratic national convention special - day 2
pbs newshour/npr democratic national convention special - day 2
pbs newshour/npr rnc special - day 3
pbs newshour/npr republican national convention special - day 3
pbs newshour/npr republican national convention special - day 3
pbs newshour/npr rnc special - day 3
pbs newshour/npr republican national convention special - day 3
pbs newshour/npr republican national convention special - day 3
pbs newshour/npr rnc special - day 2
watch tuesday nights pbs newshour/npr special from day 2 of the rnc in cleveland.
watch tuesday nights pbs newshour/npr special from day 2 of the rnc in cleveland.
pbs newshour/npr rnc special - day 1
pbs newshour/npr republican national convention special – day 1
pbs newshour/npr republican national convention special – day 1
searching for justice | part 3
changing the criminal justice system on behalf of children
changing the criminal justice system on behalf of children
democratic national convention - day 2
coverage of the democratic national convention - day 2
coverage of the democratic national convention - day 2
the trump impeachment hearings - day 2
the trump impeachment hearings - day 2
the trump impeachment hearings - day 2
democratic national convention - day 3
coverage of the democratic national convention - day 3
coverage of the democratic national convention - day 3
impeachment trial of donald trump - day 12
watch the final vote in the trump impeachment trial.
watch the final vote in the trump impeachment trial.
the trump impeachment hearings - day 4
the trump impeachment hearings - day 4
the trump impeachment hearings - day 4
searching for justice | part 4
how drug testing in alabama holds former prisoners back from creating a new life
how drug testing in alabama holds former prisoners back from creating a new life
searching for justice | part 1
free from prison after 23 years, but facing new challenges during the pandemic
free from prison after 23 years, but facing new challenges during the pandemic
watch: biden speaks after electoral college vote
watch live: biden speaks after electoral college certification results
watch live: biden speaks after electoral college certification results
searching for justice | part 2
the vicious cycle of incarceration and homelessness
the vicious cycle of incarceration and homelessness
pbs newshour/npr dnc special - day 3
pbs newshour/npr democratic national convention special - day 3
pbs newshour/npr democratic national convention special - day 3
questions for president obama: a town hall special
president barack obama joins gwen ifill for a town hall conversation in elkhart, indiana.
president barack obama joins gwen ifill for a town hall conversation in elkhart, indiana.
watch the full first presidential debate
hillary clinton and donald trump faced off for the first debate at hofstra university.
hillary clinton and donald trump faced off for the first debate at hofstra university. |
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| The Algorithm Knows Me, But Do I Know Myself |
| Posted on Tuesday, October 20 @ 00:00:19 PDT (12 reads) | |
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Doomscrolling is taking away my ability to learn who i am. I no longer know whether any thought i have throughout the day is original, something i truly feel, something i actually believe, something i am genuinely passionate about, or just a culmination of hundreds of reels floating around the stratosphere of my brain. I’m 20 years old. I’m an undergraduate student. I am quite literally still figuring everything out. I feel like i have barely scratched the surface of who i am as a human being on this planet, and somehow, i already feel like i’m failing at it.
i don’t even know if my sense of style is my own: the clothes i wear, the jewelry i like, the things i find beautiful. Sometimes i don’t even know if my sense of right and wrong is entirely mine. Are my beliefs about the world things i have actually thought through or did my algorithm feed me 100 videos of different people regurgitating the same opinion in slightly different words until it started sounding like my own voice?
how am i only 20 and already convinced that i should have done and experienced everything? Probably because i just spent five hours in bed watching people who have already gotten married, finished college, gotten a master’s degree, landed their dream job, gotten fired from that job, found another one, gotten divorced, traveled the world, figured out their sexuality, moved across the country, and reinvented themselves. For ten seconds at a time, i get to feel like i am part of all of their lives. Meanwhile, i am still in bed.
that might be the strangest thing about doomscrolling: i can consume an entire lifetime without actually living a minute of my own. Sometimes i’ll see clips of characters from my favorite shows and sitcoms and realize i’m not even close to their first-season age. I have this enormous life ahead of me. I haven’t met people yet, been to places yet, or become versions of myself i haven’t become yet, and yet doomscrolling has somehow made me feel like my life is already over before it has even really begun. That is because my phone constantly asks me to decide who i am before i’ve had the chance to find out.
one moment, i want to be the girl who lives in a cottage in the woods with farm animals. The next, i want to be a corporate girl in new york, running around in heels and living out my carrie bradshaw fantasy. One day i want to wear floral dresses and bows and be unapologetically feminine. Then i see a girl wearing the chicest skirt, boots, and jacket i have ever seen, and suddenly i wonder if that is who i am supposed to be, who i want to be, or who i already am.
one moment, i want to be the girl who lives in a cottage in the woods with farm animals. Next, i want to be a corporate girl living in new york, running around in heels and living out my carrie bradshaw fantasy. One day i want to wear floral dresses and bows and be unapologetically feminine. Then i see a girl wearing the chicest skirt, boots, and jacket i have ever seen, and suddenly i wonder if that is who i am supposed to be, who i want to be, or who i already am.
one moment i want to love my body exactly as it is. The next, i’m mentally making a list of the fillers and botox i’ll get the second i can afford them. But what if i don’t want to be put into a box? What if i don’t fit into one? What if there are phases of my life when i want to be all of those women, and phases when i want to be none of them? What if there is a year when i want to go out every weekend, wear tiny outfits and stay out until 3 a.M., And then six months when i want to wear sweats, read books and disappear into my room?
maybe that’s just… being a person.
when i look at the women around me, my mom, my grandmother, my friends’ moms and grandmothers, and i see such dynamic, creative, different people. They have their own sense of style, opinions, strange little preferences and habits, and thoughts shaped over decades of friendships, heartbreaks, mistakes, work, marriage, motherhood, travel, arguments, books, movies, conversations, and ordinary days. When i look at them, i see this beautiful spectrum of what a human life can become. Then i look at myself and wonder: is any of this actually mine?
when i look at my mom and grandmother’s generations, i think about how they could have phases without immediately turning them into identities. They could change their hair, their clothes, their hobbies, their opinions and their priorities because that was simply what they felt like doing at that point in their lives. There wasn’t an algorithm collecting millions of tiny pieces of information about what they lingered on, what they liked, and what they scrolled past, then feeding them a picture-perfect identity to aspire to. They got to become themselves slowly.
i want that.
as i enter my 20s, everyone keeps telling me that this is supposed to be such an exciting, fun decade, and i want it to be, but i don’t want to rush through it because i’m constantly watching everyone else’s life happen at once. I am ready to take all ten years of this decade to figure out who i am.
recently, i’ve started reading and writing again. I genuinely loved them when i was younger, before everything i enjoyed had to be aesthetically pleasing enough to post. Sometimes i feel like i need to go backward to move forward. I need to go searching for the middle-school version of myself. She loved books, arts and crafts, making people’s birthdays special, writing, and spending hours doing things simply because they were fun. She didn’t give a flying fuck what anyone thought of her.
okay, maybe i don’t need to recover everything about middle-school me. Some things can stay firmly in the past. The middle-school aesthetic was objectively a little questionable, but i want some of her back. I want to know what i like when no one is showing me what i should like. I want to know what i believe when no one is telling me what the correct opinion is. I want to know what i find beautiful before an algorithm tells me what beauty looks like. I want to know what i care about, what i stand for, what makes me angry, what makes me curious, and what makes me lose track of time.
i’m saniaa, i’m addicted to doomscrolling, and i’m trying not to be because there is so much more i want to notice.
i recently saw an interview where taylor swift talked about feeling things intensely, noticing everything, and experiencing life in an incredibly detailed way between the ages of 18 and 22. That idea stuck with me because i realized i can’t do that if i’m doomscrolling. I can’t notice everything around me when i’m absorbing everything happening everywhere else.
there is so much to see, so much knowledge to consume that isn’t packaged into a 15-second video, so many books to read, so many people to talk to, so many things to make badly before i learn to make them well, so many places to walk around without photographing them, so many interests to pick up and abandon, so many opinions to form and change, so many versions of myself that i haven’t met yet.
life is actually too beautiful and, yes, too “whimsical” for whimsy to just mean sticking plastic rhinestones onto face masks and phone cases because tiktok decided that was what a whimsical life looked like that week.
most importantly, none of this is a race, so why does doomscrolling make me feel like i have just run one? I can spend hours lying completely still while my heart rate rises as though i have run a marathon, except i haven’t gone anywhere. I’ve watched hundreds of people live hundreds of different lives and subconsciously asked myself to keep up with all of them. That feeling isn’t ambition; it’s anxiety.
i am 20. I don’t need to know exactly who i am yet. Figuring that out is supposed to take time. I am supposed to contradict myself; i am supposed to have phases; i am supposed to love something for six months and then never touch it again; i will be the cottage girl for a while and the new york corporate girl later, and maybe i’ll be both at the same time. Maybe i’ll become someone i can’t even imagine right now. I want those versions of me to come from living my life, not watching everyone else’s.
i have spent enough time consuming other people’s lives; i think i’m ready to get back to mine. |
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| Arthur Jafa explores complexities of Black American life |
| Posted on Tuesday, October 20 @ 00:00:19 PDT (12 reads) | |
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pbs news hour
arthur jafa explores complexities of black american life
bruce springsteen: finding america in song
bruce springsteen: finding america in song
bruce springsteen: finding america in song
bruce springsteen: finding america in song
bruce springsteen: finding america in song
bruce springsteen: finding america in song
president trump address to the nation — pbs news special report
president trump address to the nation — pbs news special report
president trump address to the nation — pbs news special report
war with iran | pbs news special report
war with iran | pbs news special report
war with iran | pbs news special report
president donald trump’s 2026 state of the union address
president donald trump’s 2026 state of the union address
president donald trump’s 2026 state of the union address
trump addresses the nation from the white house
trump addresses the nation from the white house
trump addresses the nation from the white house
president donald trumps 2025 address to congress
president donald trump on march 4, 2025, will address a joint session of congress.
president donald trump on march 4, 2025, will address a joint session of congress.
harris addresses supporters after losing 2024 presidential election
harris addresses supporters after losing 2024 presidential election
harris addresses supporters after losing 2024 presidential election
beyond the canvas | season 2 | episode 3
women of wonder
women of wonder
2020 final presidential debate
president donald trump and former vice president joe biden meet in the final debate.
president donald trump and former vice president joe biden meet in the final debate.
the trump impeachment trial - day 1
the trump impeachment trial - day 1
the trump impeachment trial - day 1
pbs newshour/politico democratic debate
the pbs newshour and politico are hosting the sixth democratic debate on dec. 1, 2019.
the pbs newshour and politico are hosting the sixth democratic debate on dec. 1, 2019.
pbs newshour iowa caucus special
pbs newshour iowa caucus special
pbs newshour iowa caucus special
beyond the canvas | season 2 | episode 1
finding one’s voice as a writer takes dedication, courage, and a willingness to reimagine the world through words on a page. In this episode of “beyond the canvas,” we sit down with novelist margaret atwood, playwright danai gurira, and others to talk about finding meaning as a writer.
finding one’s voice as a writer takes dedication, courage, and a willingness to reimagine the world through words on a page. In this episode of “beyond the canvas,” we sit down with novelist margaret atwood, playwright danai gurira, and others to talk about finding meaning as a writer.
pbs newshour new hampshire primary special
pbs newshour new hampshire primary special
pbs newshour new hampshire primary special
pbs newshour march 10th primary special coverage
pbs newshour march 10th primary special coverage
pbs newshour march 10th primary special coverage
celebrating america - a pbs newshour inauguration special
celebrating america - a pbs newshour inauguration special
celebrating america - a pbs newshour inauguration special
invisible scars | part 2
breaking the cycle of childhood trauma in rural montana
breaking the cycle of childhood trauma in rural montana
pbs newshour 2020 election update special
pbs newshour discusses this historic election and what comes next.
pbs newshour discusses this historic election and what comes next.
republican national convention - day 2
coverage of the republican national convention - day 2
coverage of the republican national convention - day 2
invisible scars | part 1
childhood trauma impacts millions of americans, and it’s having devastating consequences
childhood trauma impacts millions of americans, and it’s having devastating consequences
republican national convention - day 1
coverage of the republican national convention - day 1
coverage of the republican national convention - day 1
race matters: america after george floyd
one year after police killed george floyd, where does america go from here?
one year after police killed george floyd, where does america go from here?
witness to the siege - a pbs newshour special
witness to the siege - a pbs newshour special
witness to the siege - a pbs newshour special
president joe biden’s first joint address to congress
president joe biden will address a joint session of congress for the first time.
president joe biden will address a joint session of congress for the first time.
america in black and blue 2020: pbs newshour weekend special
pbs newshour weekend’s “america in black and blue 2020” - a special on race and policing.
pbs newshour weekend’s “america in black and blue 2020” - a special on race and policing.
pbs newshour/npr rnc special – day 4
pbs newshour/npr republican national convention special – day 4
pbs newshour/npr republican national convention special – day 4
the trump impeachment hearings - day 3
the trump impeachment hearings - day 3
the trump impeachment hearings - day 3
watch: 2020 vice presidential debate
vice president mike pence meets sen. Kamala harris in the vice presidential debate.
vice president mike pence meets sen. Kamala harris in the vice presidential debate.
the trump impeachment hearings - day 1
the trump impeachment hearings - day 1
the trump impeachment hearings - day 1
republican national convention: august 29, 2012 (part 2)
republican national convention: august 29, 2012 (part 2)
republican national convention: august 29, 2012 (part 2)
republican national convention: august 29, 2012 (part 1)
republican national convention: august 29, 2012 (part 1)
republican national convention: august 29, 2012 (part 1)
special report: america remembers 9/11
special report: america remembers 9/11
special report: america remembers 9/11
pbs newshour full state of the union special jan. 20, 2015
pbs newshour state of the union 2015 special report.
pbs newshour state of the union 2015 special report.
pbs newshour 2013 state of the union special report
pbs newshour 2013 state of the union special report
pbs newshour 2013 state of the union special report
watch the full 2012 vice presidential debate
watch the full pbs newshour 2012 vice presidential debate special
watch the full pbs newshour 2012 vice presidential debate special
democratic national convention: september 5, 2012 (part 2)
democratic national convention: september 5, 2012 (part 2)
democratic national convention: september 5, 2012 (part 2)
democratic national convention: september 6, 2012
democratic national convention: september 6, 2012
democratic national convention: september 6, 2012
democratic national convention: september 5, 2012 (part 1)
democratic national convention: september 5, 2012 (part 1)
democratic national convention: september 5, 2012 (part 1)
democratic national convention: september 4, 2012 (part 1)
democratic national convention: september 4, 2012
democratic national convention: september 4, 2012
democratic national convention: september 4, 2012 (part 2)
democratic national convention: september 4, 2012 (part 2)
democratic national convention: september 4, 2012 (part 2)
pbs newshour/npr - dnc special - day 1
pbs newshour/npr democratic national convention special - day 1
pbs newshour/npr democratic national convention special - day 1
pbs newshour/npr dnc special - day 2
pbs newshour/npr democratic national convention special - day 2
pbs newshour/npr democratic national convention special - day 2
pbs newshour/npr rnc special - day 3
pbs newshour/npr republican national convention special - day 3
pbs newshour/npr republican national convention special - day 3
pbs newshour/npr rnc special - day 3
pbs newshour/npr republican national convention special - day 3
pbs newshour/npr republican national convention special - day 3
pbs newshour/npr rnc special - day 2
watch tuesday nights pbs newshour/npr special from day 2 of the rnc in cleveland.
watch tuesday nights pbs newshour/npr special from day 2 of the rnc in cleveland.
pbs newshour/npr rnc special - day 1
pbs newshour/npr republican national convention special – day 1
pbs newshour/npr republican national convention special – day 1
searching for justice | part 3
changing the criminal justice system on behalf of children
changing the criminal justice system on behalf of children
democratic national convention - day 2
coverage of the democratic national convention - day 2
coverage of the democratic national convention - day 2
the trump impeachment hearings - day 2
the trump impeachment hearings - day 2
the trump impeachment hearings - day 2
democratic national convention - day 3
coverage of the democratic national convention - day 3
coverage of the democratic national convention - day 3
impeachment trial of donald trump - day 12
watch the final vote in the trump impeachment trial.
watch the final vote in the trump impeachment trial.
the trump impeachment hearings - day 4
the trump impeachment hearings - day 4
the trump impeachment hearings - day 4
searching for justice | part 4
how drug testing in alabama holds former prisoners back from creating a new life
how drug testing in alabama holds former prisoners back from creating a new life
searching for justice | part 1
free from prison after 23 years, but facing new challenges during the pandemic
free from prison after 23 years, but facing new challenges during the pandemic
watch: biden speaks after electoral college vote
watch live: biden speaks after electoral college certification results
watch live: biden speaks after electoral college certification results
searching for justice | part 2
the vicious cycle of incarceration and homelessness
the vicious cycle of incarceration and homelessness
pbs newshour/npr dnc special - day 3
pbs newshour/npr democratic national convention special - day 3
pbs newshour/npr democratic national convention special - day 3
questions for president obama: a town hall special
president barack obama joins gwen ifill for a town hall conversation in elkhart, indiana.
president barack obama joins gwen ifill for a town hall conversation in elkhart, indiana.
watch the full first presidential debate
hillary clinton and donald trump faced off for the first debate at hofstra university.
hillary clinton and donald trump faced off for the first debate at hofstra university. |
| ( Read More... | 20740 bytes more | comments? | ) |
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| E-aviation takes off as companies seek new era of flight |
| Posted on Tuesday, October 20 @ 00:00:19 PDT (13 reads) | |
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pbs news hour
e-aviation takes off as companies seek new era of flight
bruce springsteen: finding america in song
bruce springsteen: finding america in song
bruce springsteen: finding america in song
bruce springsteen: finding america in song
bruce springsteen: finding america in song
bruce springsteen: finding america in song
president trump address to the nation — pbs news special report
president trump address to the nation — pbs news special report
president trump address to the nation — pbs news special report
war with iran | pbs news special report
war with iran | pbs news special report
war with iran | pbs news special report
president donald trump’s 2026 state of the union address
president donald trump’s 2026 state of the union address
president donald trump’s 2026 state of the union address
trump addresses the nation from the white house
trump addresses the nation from the white house
trump addresses the nation from the white house
president donald trumps 2025 address to congress
president donald trump on march 4, 2025, will address a joint session of congress.
president donald trump on march 4, 2025, will address a joint session of congress.
harris addresses supporters after losing 2024 presidential election
harris addresses supporters after losing 2024 presidential election
harris addresses supporters after losing 2024 presidential election
beyond the canvas | season 2 | episode 3
women of wonder
women of wonder
2020 final presidential debate
president donald trump and former vice president joe biden meet in the final debate.
president donald trump and former vice president joe biden meet in the final debate.
the trump impeachment trial - day 1
the trump impeachment trial - day 1
the trump impeachment trial - day 1
pbs newshour/politico democratic debate
the pbs newshour and politico are hosting the sixth democratic debate on dec. 1, 2019.
the pbs newshour and politico are hosting the sixth democratic debate on dec. 1, 2019.
pbs newshour iowa caucus special
pbs newshour iowa caucus special
pbs newshour iowa caucus special
beyond the canvas | season 2 | episode 1
finding one’s voice as a writer takes dedication, courage, and a willingness to reimagine the world through words on a page. In this episode of “beyond the canvas,” we sit down with novelist margaret atwood, playwright danai gurira, and others to talk about finding meaning as a writer.
finding one’s voice as a writer takes dedication, courage, and a willingness to reimagine the world through words on a page. In this episode of “beyond the canvas,” we sit down with novelist margaret atwood, playwright danai gurira, and others to talk about finding meaning as a writer.
pbs newshour new hampshire primary special
pbs newshour new hampshire primary special
pbs newshour new hampshire primary special
pbs newshour march 10th primary special coverage
pbs newshour march 10th primary special coverage
pbs newshour march 10th primary special coverage
celebrating america - a pbs newshour inauguration special
celebrating america - a pbs newshour inauguration special
celebrating america - a pbs newshour inauguration special
invisible scars | part 2
breaking the cycle of childhood trauma in rural montana
breaking the cycle of childhood trauma in rural montana
pbs newshour 2020 election update special
pbs newshour discusses this historic election and what comes next.
pbs newshour discusses this historic election and what comes next.
republican national convention - day 2
coverage of the republican national convention - day 2
coverage of the republican national convention - day 2
invisible scars | part 1
childhood trauma impacts millions of americans, and it’s having devastating consequences
childhood trauma impacts millions of americans, and it’s having devastating consequences
republican national convention - day 1
coverage of the republican national convention - day 1
coverage of the republican national convention - day 1
race matters: america after george floyd
one year after police killed george floyd, where does america go from here?
one year after police killed george floyd, where does america go from here?
witness to the siege - a pbs newshour special
witness to the siege - a pbs newshour special
witness to the siege - a pbs newshour special
president joe biden’s first joint address to congress
president joe biden will address a joint session of congress for the first time.
president joe biden will address a joint session of congress for the first time.
america in black and blue 2020: pbs newshour weekend special
pbs newshour weekend’s “america in black and blue 2020” - a special on race and policing.
pbs newshour weekend’s “america in black and blue 2020” - a special on race and policing.
pbs newshour/npr rnc special – day 4
pbs newshour/npr republican national convention special – day 4
pbs newshour/npr republican national convention special – day 4
the trump impeachment hearings - day 3
the trump impeachment hearings - day 3
the trump impeachment hearings - day 3
watch: 2020 vice presidential debate
vice president mike pence meets sen. Kamala harris in the vice presidential debate.
vice president mike pence meets sen. Kamala harris in the vice presidential debate.
the trump impeachment hearings - day 1
the trump impeachment hearings - day 1
the trump impeachment hearings - day 1
republican national convention: august 29, 2012 (part 2)
republican national convention: august 29, 2012 (part 2)
republican national convention: august 29, 2012 (part 2)
republican national convention: august 29, 2012 (part 1)
republican national convention: august 29, 2012 (part 1)
republican national convention: august 29, 2012 (part 1)
special report: america remembers 9/11
special report: america remembers 9/11
special report: america remembers 9/11
pbs newshour full state of the union special jan. 20, 2015
pbs newshour state of the union 2015 special report.
pbs newshour state of the union 2015 special report.
pbs newshour 2013 state of the union special report
pbs newshour 2013 state of the union special report
pbs newshour 2013 state of the union special report
watch the full 2012 vice presidential debate
watch the full pbs newshour 2012 vice presidential debate special
watch the full pbs newshour 2012 vice presidential debate special
democratic national convention: september 5, 2012 (part 2)
democratic national convention: september 5, 2012 (part 2)
democratic national convention: september 5, 2012 (part 2)
democratic national convention: september 6, 2012
democratic national convention: september 6, 2012
democratic national convention: september 6, 2012
democratic national convention: september 5, 2012 (part 1)
democratic national convention: september 5, 2012 (part 1)
democratic national convention: september 5, 2012 (part 1)
democratic national convention: september 4, 2012 (part 1)
democratic national convention: september 4, 2012
democratic national convention: september 4, 2012
democratic national convention: september 4, 2012 (part 2)
democratic national convention: september 4, 2012 (part 2)
democratic national convention: september 4, 2012 (part 2)
pbs newshour/npr - dnc special - day 1
pbs newshour/npr democratic national convention special - day 1
pbs newshour/npr democratic national convention special - day 1
pbs newshour/npr dnc special - day 2
pbs newshour/npr democratic national convention special - day 2
pbs newshour/npr democratic national convention special - day 2
pbs newshour/npr rnc special - day 3
pbs newshour/npr republican national convention special - day 3
pbs newshour/npr republican national convention special - day 3
pbs newshour/npr rnc special - day 3
pbs newshour/npr republican national convention special - day 3
pbs newshour/npr republican national convention special - day 3
pbs newshour/npr rnc special - day 2
watch tuesday nights pbs newshour/npr special from day 2 of the rnc in cleveland.
watch tuesday nights pbs newshour/npr special from day 2 of the rnc in cleveland.
pbs newshour/npr rnc special - day 1
pbs newshour/npr republican national convention special – day 1
pbs newshour/npr republican national convention special – day 1
searching for justice | part 3
changing the criminal justice system on behalf of children
changing the criminal justice system on behalf of children
democratic national convention - day 2
coverage of the democratic national convention - day 2
coverage of the democratic national convention - day 2
the trump impeachment hearings - day 2
the trump impeachment hearings - day 2
the trump impeachment hearings - day 2
democratic national convention - day 3
coverage of the democratic national convention - day 3
coverage of the democratic national convention - day 3
impeachment trial of donald trump - day 12
watch the final vote in the trump impeachment trial.
watch the final vote in the trump impeachment trial.
the trump impeachment hearings - day 4
the trump impeachment hearings - day 4
the trump impeachment hearings - day 4
searching for justice | part 4
how drug testing in alabama holds former prisoners back from creating a new life
how drug testing in alabama holds former prisoners back from creating a new life
searching for justice | part 1
free from prison after 23 years, but facing new challenges during the pandemic
free from prison after 23 years, but facing new challenges during the pandemic
watch: biden speaks after electoral college vote
watch live: biden speaks after electoral college certification results
watch live: biden speaks after electoral college certification results
searching for justice | part 2
the vicious cycle of incarceration and homelessness
the vicious cycle of incarceration and homelessness
pbs newshour/npr dnc special - day 3
pbs newshour/npr democratic national convention special - day 3
pbs newshour/npr democratic national convention special - day 3
questions for president obama: a town hall special
president barack obama joins gwen ifill for a town hall conversation in elkhart, indiana.
president barack obama joins gwen ifill for a town hall conversation in elkhart, indiana.
watch the full first presidential debate
hillary clinton and donald trump faced off for the first debate at hofstra university.
hillary clinton and donald trump faced off for the first debate at hofstra university. |
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| New Polls Show Husted Edging Brown in Tight Ohio Senate Race |
| Posted on Tuesday, October 20 @ 00:00:19 PDT (13 reads) | |
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Two new polls show republican sen. Jon husted with a narrow lead over democrat sherrod brown in ohio’s 2026 u.S. Senate race, a reversal from a string of earlier surveys that had brown ahead.
an activote poll of 400 likely voters, conducted between september 26 and october 18 with a median field date of october 7, put husted at 50.2 percent to brown’s 49.8 percent. That 0.4-point gap is well within the poll’s 4.9-point margin of error.
activote’s analysis found the race hinges on voters in the political middle. “The race is decided in the center, where husted leads by 56% to 44%,” the firm wrote.
according to the poll, husted holds an edge among rural voters, men, white voters, voters aged 30 to 64, and those with a high school education or less. Brown leads among suburban and urban voters, women, black voters, the youngest and oldest age groups, and college-educated voters. Activote cautioned that these subgroup numbers carry a larger margin of error than the overall result, and noted that ohio does not register voters by party.
a second poll pointed the same way. The account political polls shared rasmussen reports figures from october 14 showing husted at 49 percent and brown at 47 percent among likely voters — a shift the account described as a five-point swing toward the republican since an earlier survey.
a reversal from recent trends the new numbers break from a run of polls that had shown brown with a clear advantage. A cnn survey of likely voters released october 8 had brown ahead 49 percent to 43 percent. A new york times/siena college poll showed him up 49 to 46. A marist poll gave him an eight-point lead, 51 to 43.
brown is seeking to reclaim the senate seat he lost to sen. Bernie moreno (r-oh) in 2024. Husted, by contrast, has never won the seat in a statewide election — republican gov. Mike dewine appointed him last year after then-sen. Jd vance left to become vice president.
president trump, who carried ohio by roughly 11 points in 2024, has endorsed husted and campaigned for him this month. The national republican senatorial committee has labeled brown a “two-time loser,” while brown’s campaign manager, patrick eisenhauer, has called husted “for sale.” |
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| Norse/Saints notes |
| Posted on Tuesday, October 20 @ 00:00:19 PDT (12 reads) | |
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Northern kentucky university volleyball head coach liz hart would rather not talk about the streak.
but people are starting to notice nku’s 10 straight volleyball wins, including an 8-0 string that has the norse (13-6 overall) tied with wright state atop the horizon league standings going into tuesday’s 6 p.M. Match against the raiders in dayton. (The game can be seen on espn+.)
“i think it’s good to have social media presence and … excitement, but for us, no, we don’t, we don’t talk about it at all,” hart said.
word has nevertheless gotten around about what nku is doing.
“i have been reminded by my one of my professors every week,” senior middle blocker ivey stocks says.
stocks leads the team with 197 kills and 82 blocks.
“i think i like to hit more, but it is fun to like get a stuffed block on someone,” she says.
sophomore defensive specialist/libero daisy cluxton has 321 digs. Her strategy is simple.
“my mentality, honestly, back on defense is just to keep the ball off the ground,” cluxton said. “And i’ll take my speed to my advantage, and i just kind of run around back there and try to keep the ball off the ground.”
sophomore setter abby pickard has 776 assists. She said she’s paying more attention to what the other team is doing.
“i’ve been setting my whole life, so that comes more natural, but working on having a higher iq and seeing what the other side of the court does and what their blocking scheme is what helps me put my attackers in like better situations to get kills,” she said.
if you count last season, nku’s regular-season run against league teams is 21 games.
“we’ve had a really strong team the past two years,” hart said. “And so i think honestly, just because we are just so focused on the process and getting better each week and making sure that we’re getting better each day at practice, i think that’s where our head’s at, and i think that just allows us to make sure that we’re keeping the right focus.”
nku women’s soccer sets one record, ties another vs. Purdue fort wayne
sunday’s 7-0 win over the mastodons is the program’s largest victory margin over a horizon league opponent since the norse joined ncaa division i, and it tied a single-game record, matching a 7-1 win over youngstown state in 2017.
megan molner and and macey blanton each scored two goals. Molner leads the team with 11.
nku improved to 3-3-2 in the league and 7-5-3 overall. The norse are seventh in the league headed into thursday’s match at detroit mercy.
the nku men’s team’s woes, meanwhile continued. Saturday’s 3-1 loss to robert morris extended the winless streak to 0-5-1. The norse fell to 1-10-2 overall and 0-4-2 in the league headed into tuesday’s match at xavier.
nku men’s and women’s cross country
the norse women and men finished third and fourth, respectively, in friday’s eagle/knight invitational at eagle trace golf course near morehead.
in the women’s 6k race, brittany arnold led nku’s women, finishing eighth in 22:29.31. Grace biddle was ninth in 22:34.97, sami govey was 15th in 23:20.20, julia verhoff was 17th in 23:29.75, and carlie condit was 20th in 23:47.19.
in the men’s 8k, nathan ruth led nku, finishing 16th in 26:23.39. Brady messer wfas 19th in 26:45.74, noah towne was 23rd in 27:19.79, gregory beard was 30th in 28:18.15, and brayden rice was 36th in 30:04.31.
the norse finish the season at the horizon league championships oct. 31 in clinton, pennsylvania.
four norse compete at east regional championship
four members of nku’s women’s triathlon finished in the top 100 at the women’s collegiate triathlon east regional championship on saturday at lanier islands in buford, georgia.
the race included a 750-meter (0.46-mile) swim, a 20-kilometer (12-4-mile) bike ride and, and 5k (3.1-mile) run. Charlotte cunningham led the norse with a 70th-place overall finish. In a final time of 1 hour, 18 minutes and 30 seconds (a 13:08 swim, 40: 22 ride and 22:21 run.
maggie wilson finished in 76th overall in 1:19:43, including a team-fastest 38:43 on the bike. Tia weiss (1:26:39) and fallon bright (1:28:55) were 94th and 97th, respectively.
saints football falls to ashland
ashland’s 27 unanswered first-half points were all the eagles needed in saturday’s 48-10 win at republic bank field.
thomas more (1-6, 1-4 in the great midwest athletic conference) gained just 237 yards, with only 20 on the ground. Ashland (2-5, 2-3) gained 497.
saints quarterback ben chesser was 18-of-36 for 217 yards, a touchdown pass to numehnne gwilly and five interceptions.
the saints take their final road trip of the season next saturday lake erie college. Kickoff is scheduled for 2 p.M. In painesville, ohio.
thomas more soccer
the saints men and women are both in third place in the gmac.
the men (7-1-3 in conference and 9-3-3 overall) lost to cedarville, 3-2 on thursday and salvaged a 0-0 tie saturday at tiffin thanks to joey jones’ eight saves.
titouan fraslin and ramzi termanini scored for thomas more.
termanini leads the team with five goals, and edward longhurst has seven assists. Jones has a 0.56 goals-against average with 37 saves and nine shutouts.
the saints play their last home game against findlay at 5 p.M. Thursday and travel to ashland on saturday and kentucky wesleyan on oct. 27.
thomas more’s women (8-1-2 in conference and 10-1-4 overall) extended their undefeated (5-0-2) streak to seven games after saturday’s 0-0 match at tiffin. Credit the saints’ defense – just one goal allowed since sept. 24.
the saints have scored 31 goals an allowed only seven. Ivy hoffman has eight goals, josie gruber is next with seven, alexis harden has five, and andjela popovic has four and a team-high four assists. Goalkeeper emma yeager has a 0.42 goals-against average with 49 saves and seven shutouts.
thomas more men’s golf
the saints finished 19th at the 54-hole doc spragg invitational saturday at findlay country club.
junior aden walls was the top finisher for the saints, placing in a tie for 69th with a score of 13-over par 229 (73, 79, 77). Senior nathan resing tied for 72nd with a 230 (78, 78, 74), junior ben egan tied for 81st at 233 (75, 74, 84), and freshmen tucker ward and tyler brandstetter tied for 92nd at 239.
missouri-st. Louis won the team title with a 16-under par 200, and the tritons’ ludvig granlund and logan mayo tied for first at 9-under 207.
thomas more finishes the fall season at the kentucky wesleyan invitational saturday and sunday at the pearl club in owensboro.
a rough volleyball weekend
thomas more lost three matches this weekend at the crossover tournament in hammond, indiana.
on friday, the saints lost to illinois-springfield, 3-1, and upper iowa 3-0, followed by saturday’s 3-0 loss to william jewell college.
the saints return to gmac play when they host ashland at 6 p.M. Friday and take on ohio dominican at 1 p.M. Saturday in columbus. |
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| Recurrent CNVs in constitutional CMA: a ClinGen-anchored single-center postnatal |
| Posted on Tuesday, October 20 @ 00:00:19 PDT (12 reads) | |
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Abstract
background:
recurrent copy-number variants (cnvs) mediated by low-copy repeats or segmental duplications constitute an important subset of constitutional chromosomal microarray analysis (cma) findings. Although acmg/clingen standards have improved cnv classification, the burden of recurrent cnvs is not routinely quantified as a canonical, interval-matched, direction-specific category in clinical cma output. We applied a strict clingen-anchored framework to quantify recurrent genomic disorder intervals in a consecutive single-center cma series.
methods:
constitutional array-cgh and snp-array records from a single center (2014–2026) were retrospectively reviewed, including 1,661 postnatal probands and 401 prenatal samples, with aneuploidies excluded. Recurrent regions were defined using the clingen dosage sensitivity map and restricted to canonical intervals presumed to be mediated by non-allelic homologous recombination. Assignment required breakpoint concordance with the flanking low-copy repeat blocks and canonical interval size; terminal, unbalanced, and atypical imbalances were excluded. All records were re-curated against a single clingen release, with earlier grch37 coordinates converted to grch38.
results:
pathogenic or likely pathogenic findings were identified in 278/1,661 postnatal probands (16.74%) and 28/401 prenatal samples (6.98%). Recurrent cnvs were detected in 92/1,661 postnatal (5.54%, 95% ci 4.54–6.74) and 17/401 prenatal cases (4.24%, 95% ci 2.66–6.68). Pathogenic/likely pathogenic cnvs were found in 66/92 postnatal (71.74%) and 7/17 prenatal carriers (41.18%); the remaining findings were of uncertain significance or benign. Pathogenic recurrent cnvs thus accounted for 66/278 (23.74%) of postnatal and 7/28 (25.00%) of prenatal non-aneuploid pathogenic findings. Proximal 22q11.21 and 16p11.2 were most frequent. Deletions predominated postnatally (64/93, 68.82%); duplications comprised 11/17 (64.71%) of prenatal recurrent cnvs. Postnatal pathogenic recurrent-cnv yield was 58/1,589 (3.65%) in phenotype-driven testing (no suspected recurrent-cnv syndrome) and 6/19 (31.58%) with syndrome-specific suspicion; neurodevelopmental referrals contributed most cases.
conclusion:
clingen-defined recurrent cnvs were a substantial component of constitutional cma findings. However, only about three-quarters of postnatal and fewer than half of prenatal carriers harbored pathogenic/likely pathogenic cnvs, indicating that a recurrent-region label alone is insufficient for interpretation. These findings support region- and dosage-specific reporting, with evidence-based classification distinguished from clinical interpretation, particularly for prenatal findings and inherited duplications, where the same label may have different patient-specific implications.
1 introduction
copy-number variants (cnvs) are a key molecular cause of intellectual disability, autism, congenital malformations, and pregnancy loss. Chromosomal microarray analysis (cma), which identifies submicroscopic cnvs across the genome, is the primary cytogenomic test recommended for these indications in the postnatal setting. The same first-tier recommendation also applies prenatally for fetuses with significant structural anomalies detected on ultrasound and for assessing intrauterine fetal loss and stillbirth when cytogenetic testing is performed (vissers et al., 2016; ; shao et al., 2021).
many clinically important constitutional cnvs occur at recurrent genomic disorder loci that are typically formed by flanking low-copy repeats or segmental duplications, which predispose to non-allelic homologous recombination (nahr)-mediated deletions and reciprocal duplications with clustered or broadly shared breakpoints. These recurrent cnvs are well recognized in neurodevelopmental and congenital disease settings, but their clinical consequences are highly locus- and dosage-dependent, with variable expressivity and incomplete penetrance across regions and between reciprocal deletion and duplication states (; ; ; smajlagi? Et al., 2021). This asymmetry complicates clinical interpretation and requires the two reciprocal dosage states to be evaluated separately, a distinction especially critical in the prenatal context, where low-penetrance variants are detected before phenotypic manifestation and are frequently inherited, even in the face of variable expressivity (; ). Recent prenatal alignment work also highlights persistent variability in how low-penetrance clingen recurrent cnvs are classified and reported across laboratories (shear et al., 2025; soares et al., 2026).
these variants are individually rare but collectively common: in an unselected newborn cohort, recurrent neurodevelopmental cnvs had a cumulative prevalence of 0.48% (?1 in 200 live-born children) (smajlagi? Et al., 2021). Their clinical burden is locus-specific, with population and biobank studies showing variable prevalence across regions and broad phenotypic associations with neurodevelopmental and medical outcomes (smajlagi? Et al., 2021; ).
clingen dosage curation and acmg/clingen cnv interpretation standards provide a framework for more consistent cnv classification and reporting (; ). Several studies have already used clingen or clingen-listed recurrent loci in related ways: kang et al. Quantified pathogenic recurrent cnvs in a prenatal cma cohort using clingen hi/ts-based region selection, xue et al. Systematically classified 22q11.2 recurrent cnvs using clingen curation, and broader population studies have estimated prevalence or risk for predefined recurrent cnv loci (; smajlagi? Et al., 2021; xue et al., 2021; ; vaez et al., 2024). However, prior approaches have generally been region-specific, phenotype-specific, population-based, or based on selected recurrent-locus sets, rather than on a consecutive series of diagnostic cma evaluations against canonical clingen-curated recurrent intervals. In addition, studies using clingen in this area have typically relied on dosage-sensitivity–based locus selection, overlap-based inclusion, or single-region curation, rather than restricting the recurrent category to cnvs that match established recurrent interval boundaries and dosage direction. Therefore, this study aimed to quantify canonical clingen-defined recurrent genomic disorder intervals in a consecutive single-center constitutional cma series and to distinguish their pathogenic fraction from variants of uncertain significance, while preserving prenatal/postnatal context, referral indication, and deletion/duplication direction.
2 materials and methods
2.1 study design and setting
this retrospective review analyzed constitutional array-cgh and snp-array data from the medical genetics department at trakya university. Only cases that underwent cma were included in the study. The overall laboratory archive covered june 2014-may 2026; postnatal records were available from 2014 onward, whereas prenatal cma records were available from 2016 onward. The postnatal cohort included 1,661 unique probands (parental/repeat samples excluded); the prenatal cohort included 401 fetal samples (amniocentesis, cvs, cordocentesis). All aneuploidies were excluded. The analysis focused solely on subchromosomal cnvs, classified according to the american college of medical genetics and genomics (acmg)/clinical genome resource (clingen) guidelines (). The full acmg/clingen curation of recurrent cnvs is provided in supplementary table s2. Pathogenic/likely pathogenic findings were counted as primary anomalies; vus were reported separately. Ethics approval was obtained (tÜtf-gobaek 2026/170) and written informed consent was provided. A subset of the patients included in this cohort has been reported previously in the context of different research questions and phenotypic or cytogenetic analyses (; ; ; yalcintepe et al., 2022).
2.2 dna isolation and cma analysis
genomic dna was extracted from amniotic fluid and chorionic villi using the qiaamp dna mini kit (qiagen, hilden, germany), and from cord blood and peripheral blood using the qiaamp dna blood midi kit (qiagen, hilden, germany), following the manufacturers’ protocols. Cma was performed using a 180k cgh + snp oligonucleotide array (isca design, agilent, santa clara, ca, united states) until january 2024; thereafter, the cytoscan ht-cma 96f assay (thermo fisher scientific, waltham, ma, united states) was used. Data were analyzed with cytogenomics 2.7 (agilent) and chromosome analysis suite 4.5.0.34 (thermo fisher), respectively, according to standard manufacturer-recommended workflows.
all cnv calls generated by the software were manually reviewed. Cnvs were considered for further analysis if they met at least one of the following criteria: (i) size ?100 kb, (ii) involved ?20 consecutive probes, or (iii) overlapped a known disease-associated gene or recurrent region, regardless of size or probe count.
2.3 recurrent cnv definition, assignment and classification
recurrent cnv regions were defined using the clingen dosage sensitivity map (region curation results, 28 april 2026; grch38/hg38), which comprises 48 curated recurrent genomic disorder regions (; ). A reference list of all 48 clingen-curated recurrent regions, including isca identifiers, grch38 coordinates, clingen haploinsufficiency/triplosensitivity scores, the short region labels used throughout this manuscript, and pooled penetrance estimates from () where a corresponding region was analyzed, is provided in supplementary table s1; case-level data are given in supplementary table s2.
cnv region assignment followed a predefined stepwise procedure. First, overlap with a clingen-curated recurrent region was screened. Second, cnvs were assigned when their array-defined boundaries were compatible with the flanking low-copy repeat (lcr) blocks and their size was consistent with the canonical interval, taking account of platform resolution, probe coverage, and coordinate conversion. Minor endpoint differences were accepted when they remained consistent with the same canonical lcr-defined interval; exact coordinate matching was not required. Third, substantially larger or smaller, terminal, complex, unbalanced, or merely overlapping cnvs were excluded unless they matched a recognized clingen interval; overlap with a clingen locus or dosage-sensitive gene alone was not sufficient. Fourth, adjacent or nested intervals were resolved using isca/clingen region names and grch38 coordinates (supplementary table s1). Since recurrent genomic disorder regions arise from non-allelic homologous recombination between fixed flanking lcrs, breakpoints cluster within defined lcr blocks (); assignment therefore used breakpoint concordance and size consistency at array resolution rather than a percentage-overlap cut-off. Flanking low-copy repeat block boundaries were taken from the clingen recurrent cnv track (v2.1, grch38). All assignments were re-curated against the current clingen release and coordinates from earlier grch37 records were converted to grch38, ensuring a single reference framework for the entire series.
region assignment and pathogenicity classification were treated as separate steps. Each recurrent cnv was classified independently under the 2019 acmg/clingen technical standards () as pathogenic/likely pathogenic, of uncertain significance, or benign, with deletions scored against haploinsufficiency and duplications against triplosensitivity evidence for the same region. We applied section 5 (inheritance) when parental data were available, but it did not change the classification in any case. We recorded inheritance information descriptively, and for these recurrent cnvs, we determined the final category using sections 2 (overlap with established dosage-sensitive regions) and 3 (number of protein-coding genes in the interval) rather than the inheritance pattern. Dosage scores, evidence codes, and point scores for every recurrent cnv are given in supplementary table s2. Yield estimates were calculated per carrier rather than per event, since a small number of carriers harbored more than one recurrent cnv.
2.4 referral indication and test purpose
referral indications were categorized as postnatal (neurodevelopmental/neurological disorders; congenital, dysmorphic and sensory anomalies; growth and head-size disorders; syndromic and familial indications; reproductive and sexual development disorders; and other systemic/miscellaneous indications) and prenatal (abnormal ultrasound, advanced maternal age, positive screening, other). Test purpose was stratified as targeted, confirmatory, characterizing, or diagnostic; the diagnostic stratum (phenotype-driven testing without prior suspicion of a specific recurrent cnv syndrome) served as the denominator for phenotype-driven yield estimates.
2.5 statistical analysis
proportions are reported with 95% wilson confidence intervals, and estimates from strata with small denominators should be read together with these intervals rather than in isolation. The postnatal and prenatal cohorts differed in size, study period, and ascertainment and were described in parallel rather than compared directly; all comparisons are descriptive and not corrected for multiple testing.
3 results
3.1 cohort characteristics
we distinguished recurrent-cnv carriers (n = 109) from recurrent-region observations/events (n = 110); one postnatal carrier harbored two independent recurrent cnvs, both documented in supplementary table s2 and included in event-based regional analyses. All yield estimates were calculated per carrier. A pathogenic or likely pathogenic copy-number finding was identified in 278/1,661 postnatal probands (16.74%, 95% ci 15.02–18.61) and 28/401 prenatal samples (6.98%, 95% ci 4.87–9.91); variants of uncertain significance were identified in 58/1,661 postnatal probands (3.49%) and 23/401 prenatal samples (5.74%), with recurrent-region findings in 22/58 (37.93%) and 8/23 (34.78%), respectively. Recurrent cnvs were identified in 92/1,661 postnatal probands (5.54%, 95% ci 4.54–6.74) and 17/401 prenatal samples (4.24%, 95% ci 2.66–6.68). Pathogenic/likely pathogenic cnvs were found in 66/92 postnatal (71.74%) and 7/17 prenatal carriers (41.18%); the remaining findings were of uncertain significance or benign. Pathogenic recurrent cnvs therefore represented 66/278 (23.74%) of postnatal and 7/28 (25.00%) of prenatal non-aneuploid pathogenic findings, corresponding to 66/1,661 postnatal probands (3.97%) and 7/401 prenatal samples (1.75%). Fetal ultrasound anomaly was the primary indication in 348/401 prenatal cases (86.78%). Among fetuses referred for an ultrasound anomaly, 12/348 (3.45%) carried a recurrent cnv and 6/348 (1.72%) carried a pathogenic recurrent cnv. Table 1 summarizes cohort characteristics, and figure 1 shows the study flowchart.
table 1
| characteristic | postnatal | prenatal |
|---|---|---|
| probands/samples, n | 1,661 | 401 |
| study period | 2014–2026 | 2016–2026 |
| pathogenic finding (non-aneuploidy), n (%, 95% ci) | 278 (16.74, 15.02–18.61) | 28 (6.98, 4.87–9.91) |
| recurrent cnv carriers, n (%, 95% ci) | 92 (5.54, 4.54–6.74) | 17 (4.24, 2.66–6.68) |
| recurrent, pathogenic/likely pathogenic, n | 66 | 7 |
| pathogenic recurrent, % of all pathogenic findings | 23.74% | 25.00% |
| distinct clingen regions (all classifications), n | 23 | 9 |
| deletion-only/duplication-only recurrent-cnv carriers, n
|
characteristics of the postnatal and prenatal cohorts.
one postnatal carrier (p025) had both a recurrent deletion and a recurrent duplication and is excluded only from this dosage-direction breakdown, not from the cohort totals. Both cnvs, are included in the event-level counts in table 2 and supplementary table s2.
figure 1
region- and direction-specific counts, along with their acmg/clingen classifications, are given in table 2. The most frequent postnatal entities were 22q11.21 proximal deletion (digeorge syndrome), 16p11.2 proximal (bp4–bp5), xp22.31 (sts), 7q11.23 proximal (williams–beuren), 17q12 (hnf1b; renal cysts and diabetes), and 15q11.2–q13.1 (prader–willi/angelman). All 1q21.1 carriers fell within the distal (bp3–bp4, gja5) subregion; 7q11.23 proximal (williams–beuren) and 17q21.31 (kansl1; koolen–de vries) were observed only in postnatal cases. In one postnatal carrier, the co-occurring second lesion was itself a recurrent region, so that this patient carried two independent recurrent loci (10q11.22–q11.23 duplication +15q11.2 bp1–bp2 deletion). Of the 46 inherited cnv carriers (35 postnatal, 11 prenatal), one transmitting parent had a documented diagnosis (table 1). All 11 prenatal transmitting parents were recorded as clinically unaffected; postnatal parental status was derived from referral records.
table 2
| recurrent region | hi | ts | post del | post dup | pre del | pre dup | total | deletion | duplication |
|---|---|---|---|---|---|---|---|---|---|
| 22q11.21 proximal (a–d, tbx1) | 3 | 3 | 13 | 5 | 1 | · | 19 | p | p |
| 16p11.2 proximal (bp4–bp5, tbx6) | 3 | 3 | 9 | 2 | 1 | · | 12 | p | p |
| xp22.31 (sts) | 3 | 40 | 3 | 3 | 1 | 2 | 9 | p | b |
| 1q21.1–q21.2 distal (bp3–bp4, gja5) | 3 | 2 | 3 | 2 | 1 | 3 | 9 | p | vus |
| 7q11.23 proximal (eln, williams–beuren) | 3 | 3 | 5 | 2 | · | · | 7 | p | p |
| 17q12 (hnf1b) | 3 | 3 | 4 | 1 | 1 | · | 6 | p | p |
| 15q11.2 (bp1–bp2, nipa1) | 3 | 40 | 4 | 1 | 1 | · | 6 | p | b |
| 15q11.2–q13.1 (class ii, bp2–bp3, pws/as) | 3 | 3 | 6 | · | · | · | 6 | p | — |
| 16p13.11 (bp2–bp3, myh11) | 2 | 2 | 1 | 4 | · | · | 5 | vus | vus |
| 22q11.1–q11.21 (ces, cecr2) | 0 | 3 | 2 | 2 | · | · | 4 | vus | p |
| 3q29 (dlg1) | 3 | 1 | 2 | 2 | · | · | 4 | p | vus |
| 22q11.23 distal type iii (f–g, smarcb1) | 3 | 1 | · | · | · | 4 | 4 | — | vus |
| 15q13.1–q13.2 (bp3–bp4, apba2) | 1 | 0 | 1 | 1 | · | 1 | 3 | vus | vus |
| 22q11.21–q11.22 distal type i (d–e) | 3 | 1 | 1 | 1 | · | · | 2 | p | vus |
| 16p11.2 distal (bp2–bp3, sh2b1) | 3 | 1 | 1 | 1 | · | · | 2 | p | vus |
| 2q13 distal (bcl2l11) | 2 | 1 | 2 | · | · | · | 2 | vus | — |
| 22q11.21 central (b–d, crkl) | 2 | 1 | 2 | · | · | · | 2 | vus | — |
| 7q11.23 distal (hip1) | 2 | 1 | 1 | · | · | · | 1 | vus | — |
| 8p23.1 (gata4) | 3 | 2 | · | 1 | · | · | 1 | — | vus |
| 10q11.22–q11.23 (lcr c–d) | 1 | 1 | · | 1 | · | · | 1 | — | vus |
| 15q13.3 (bp4–bp5, chrna7) | 3 | 1 | 1 | · | · | · | 1 | p | — |
| 15q13.3–q14 (bp5–bp6, grem1) | 1 | 0 | 1 | · | · | · | 1 | vus | — |
| 17q11.2 (type 2, nf1) | 3 | 2 | 1 | · | · | · | 1 | p | — |
| 17q21.31 (kansl1) | 3 | 1 | 1 | · | · | · | 1 | p | — |
| 15q24.1–q24.2 (lcr a–c) | 3 | 1 | · | · | · | 1 | 1 | — | p |
| total | | | 64 | 29 | 6 | 11 | 110 | | |
event-level recurrent cnvs by clingen region, dosage sensitivity, dosage direction, and acmg/clingen classification in postnatal and prenatal cases.
hi, clingen haploinsufficiency score; ts, clingen triplosensitivity score (40, dosage sensitivity unlikely); post, postnatal; pre, prenatal; p, pathogenic; vus, variant of uncertain significance; b, benign; —, direction not observed. The deletion and duplication columns show the acmg/clingen classification for each dosage direction in that region. Counts are event-based (110 cnvs in 109 carriers). Region labels and coordinates follow supplementary table s1.
we categorized referral indications into six groups: neurodevelopmental/neurological, congenital/dysmorphic/sensory, growth/head size, syndromic and familial, reproductive/sexual development, and other systemic/miscellaneous. Each proband was assigned to a single primary indication, and these categories collectively represented the full postnatal denominator (table 3). Neurodevelopmental referrals formed the largest group and accounted for 38/66 pathogenic recurrent-cnv carriers (57.58%), the largest contribution among indication groups. Pathogenic recurrent-cnv yield was similar across indication groups, ranging from 2.94% to 6.52%, with broadly overlapping confidence intervals that preclude ranking any single indication as higher-yield. Table 3 reports pathogenic recurrent-cnv carrier yield, whereas figure 2 shows the event-based regional composition of all recurrent cnvs by referral indication. Yields also differed by test purpose, being much higher for targeted requests than in phenotype-driven testing (table 4).
table 3
| referral indication group | probands | pathogenic recurrent cnv | yield (%) | 95% ci |
|---|---|---|---|---|
| neurodevelopmental and neurological disorders | 952 | 38 | 3.99 | 2.92–5.43 |
| congenital, dysmorphic and sensory anomalies | 374 | 11 | 2.94 | 1.65–5.19 |
| growth and head-size disorders | 66 | 3 | 4.55 | 1.56–12.53 |
| syndromic and familial indications | 159 | 9 | 5.66 | 3.01–10.41 |
| reproductive and sexual development disorders | 64 | 2 | 3.13 | 0.86–10.70 |
| other systemic and miscellaneous indications | 46 | 3 | 6.52 | 2.24–17.5 |
| total | 1661 | 66 | 3.97 | 3.14–5.02 |
pathogenic recurrent-cnv frequency by referral-indication group in all postnatal probands.
figure 2
table 4
| test purpose | requests | pathogenic recurrent cnv | yield (%) | 95% ci |
|---|---|---|---|---|
| diagnostic (phenotype-driven, hypothesis-free) | 1,589 | 58 | 3.65 | 2.83–4.69 |
| targeted (specific recurrent cnv syndrome suspected) | 19 | 6 | 31.58 | 15.36–53.99 |
| confirmatory (cnv already identified) | 13 | 2 | 15.38 | 4.33–42.24 |
| characterizing (known karyotype abnormality) | 40 | 0 | 0.0 | 0.0–8.76 |
| total | 1661 | 66 | 3.97 | 3.14–5.02 |
pathogenic recurrent-cnv frequency by the purpose for which the array was requested (postnatal probands).
4 discussion
anchoring recurrent-cnv calls to clingen-curated regions and preserving dosage direction allowed us to quantify canonical recurrent cnvs as a distinct and substantial component of constitutional cma reporting. Applying this framework, we found that recurrent cnvs accounted for 66/278 (23.74%) of postnatal and 7/28 (25.00%) of prenatal non-aneuploid pathogenic/likely pathogenic copy-number findings when only pathogenic recurrent cnvs were counted, indicating that aggregate reporting alone may make the contribution of canonical recurrent loci less visible. Notably, when each recurrent cnv was classified individually under the 2019 acmg/clingen standards, pathogenic/likely pathogenic cnvs were found in only 66/92 postnatal (71.74%) and 7/17 prenatal recurrent-cnv carriers (41.18%); the remaining findings were of uncertain significance or benign. This directly quantifies the central observation that a recurrent-region label alone does not equate to pathogenicity.
the postnatal recurrent-cnv rate of 92/1,661 (5.54%) exceeded the 0.48% live-birth estimate from the moba cohort, as expected, given that this study focused on a tertiary diagnostic group enriched for neurodevelopmental, congenital, dysmorphic, growth-related, and syndromic/familial referral indications (smajlagi? Et al., 2021; ). Population prevalence and diagnostic yield therefore capture different aspects of the recurrent-cnv burden, and even well-characterized disorders such as williams–beuren and 22q11.2 deletion syndromes may be underrepresented in population cohorts owing to variable expressivity, incomplete penetrance, ascertainment bias, and other methodological differences (smajlagi? Et al., 2021; ). In our postnatal cohort, pathogenic recurrent cnvs represented 23.74% of all pathogenic findings. Postnatal series applying the same acmg framework but a broader recurrent definition, one that also includes terminal and single-gene microdeletion/duplication syndromes, have reported higher proportions: 21/35 (60.0%) in miclea et al., 76/127 (59.8%) in hu et al., And a similar predominance of recurrent over non-recurrent pathogenic cnvs in wu et al. (; ; Wu et al., 2023). At the cohort level, our pathogenic recurrent-cnv yield of 66/1,661 (3.97%) was below the 6.6% and 6.1% reported in the neurodevelopmental cohorts of wayhelová et al. And cheng et al., Respectively (; wayhelova et al., 2019). Within our neurodevelopmental/neurological referral group, the yield was 38/952 (3.99%), close to the overall postnatal estimate and still below both reported rates. Differences in the definition of “recurrent” may contribute to this discrepancy. For example, wayhelová et al. Included 1q43–q44 and 22q13.3 deletion syndromes in their recurrent category, whereas our analysis was restricted to canonical nahr-mediated intervals curated by clingen as recurrent. Notably, despite these quantitative differences, the predominance of deletions over duplications (approximately two-thirds) was consistent across all series, supporting a shared mechanistic basis for recurrent structural variation. When variants of uncertain significance were excluded, the overall non-aneuploid pathogenic or likely pathogenic yield of 16.74% fell within the expected 15%–20% range for referred postnatal cma cohorts ().
in our prenatal cohort, clingen-defined recurrent cnvs were detected in 17/401 samples (4.24%), with pathogenic recurrent cnvs detected in 7/401 (1.75%). Han et al., Who defined recurrence by complete or partial overlap with decipher-listed microdeletion/microduplication syndromes but classified variants under the same acmg/clingen framework, reported an almost identical pathogenic recurrent-cnv rate of 134/7,645 (1.75%) and a total recurrent-cnv rate of 2.1% (). Kang et al. Reported pathogenic recurrent-cnv frequencies of 83/7,078 (1.17%) overall and 40/1,781 (2.25%) in their fetal ultrasound-anomaly group (). Although both studies screened overlapping sets of recurrent loci, their cnv inclusion criteria differed. Kang et al. Included cnvs that encompassed or partially overlapped a recurrent region, provided that the region’s corresponding clingen hi or ts score was 1, 2, or 3. In our ultrasound-anomaly subgroup, the pathogenic recurrent-cnv yield was 6/348 (1.72%; 95% ci 0.79–3.71). These estimates provide descriptive context rather than evidence of equivalent diagnostic yield, given differences in cnv inclusion and classification, referral grouping, and cohort size. In the comparison with han et al., Dosage distribution also differed: their prenatal recurrent cnvs were deletion-predominant (66%), whereas duplications accounted for 11/17 recurrent cnvs (64.71%) in our cohort, several of which had low or uncertain penetrance and were classified as vus rather than pathogenic. In this series, the pathogenic fraction was lower among prenatal duplications than deletions, consistent with the observation that a recurrent-region label does not by itself establish diagnostic certainty; the small number of prenatal carriers limits generalization of this distribution.
test-purpose stratification is crucial because targeted, confirmatory, and phenotype-driven referrals have different clinical implications. For pathogenic recurrent cnvs, targeted requests had the highest observed per-test yield, 6/19 (31.58%), but contributed 6/66 carriers (9.09%). Phenotype-driven diagnostic testing had a lower yield, 58/1,589 (3.65%), but accounted for 58/66 carriers (87.88%), reflecting the much larger number of referrals in this group (table 4). Additionally, since a “targeted” request may focus on recurrent cnv syndromes in one lab and on single-gene or other syndromes in another, yield comparisons across labs are not valid unless they specify request types.
regional composition analysis adds another layer to the indication-based yield results. In neurodevelopmental cases, 22q11.21 proximal and 16p11.2 proximal stood out, while recurrent cnvs in the syndromic and familial referral-indication group most frequently involved 7q11.23 proximal (williams–beuren) and 22q11.1–q11.21 (ces) (figure 2). Considering all recurrent-cnv carriers regardless of classification, 84/92 (91.30%) were identified through phenotype-driven diagnostic testing (without prior suspicion of a specific recurrent cnv syndrome), 6/92 (6.52%) through targeted requests and 2/92 (2.17%) through confirmatory testing. Of these 84 diagnostic carriers, 58 harbored pathogenic/likely pathogenic recurrent cnvs (table 4); the remainder carried only vus or benign recurrent cnvs. Genome-wide testing can identify cnvs associated with nonspecific phenotypes or variable expressivity, including recurrent cnvs with incomplete penetrance (; ). Loci in the congenital and dysmorphic group are more dispersed, but small subgroup sizes require caution when interpreting these results.
the regional spectrum displayed clinical heterogeneity. One category comprised deletion-prone genomic disorders with well-described clinical phenotypes, such as 22q11.21 proximal, 7q11.23 proximal, 15q11.2–q13.1, 17q12 and 17q21.31 rearrangements (). In our cohort, however, no syndrome-specific suspicion was recorded at referral for any of the 13 postnatal carriers of the proximal 22q11.21 deletion (supplementary table s2). A second category comprised reciprocal susceptibility loci such as 16p11.2 proximal, 1q21.1–q21.2 distal, 3q29, 16p13.11 (bp2–bp3) and 15q13.3 (bp4–bp5), where deletions and duplications are both possible but vary in penetrance, expressivity, and confidence in interpretation (). The third category consisted of low-penetrance or direction-sensitive duplications such as xp22.31, 22q11.23 distal type iii, and the benign 15q11.2 bp1–bp2 duplication (). Only one of the 35 postnatal transmitting parents had a documented clinical diagnosis: the mother who transmitted a 3q29 deletion, who has attention-deficit/hyperactivity disorder, a recognized component of that phenotype (). Parental clinical information was obtained from referral records; parents were not clinically re-evaluated for this study. Reduced penetrance and variable expressivity complicate counseling on inherited findings (; ). These results support reporting recurrent cnvs based on both locus and dosage direction, rather than solely on region name.
pooled penetrance estimates are derived from case–control and population studies with their own ascertainment criteria and phenotype definitions; we therefore used them only as literature-based context for regional interpretation, not as estimates applicable to the present diagnostic cohort. This direction-specific interpretation is informed by clingen dosage sensitivity scores and by , who reported higher penetrance for deletions than for reciprocal duplications at several loci represented here, including 22q11.2, 17q12 and distal 1q21.1. Clingen likewise provides stronger haploinsufficiency than triplosensitivity evidence at some loci; triplosensitivity is considered unlikely for the xp22.31 and 15q11.2 bp1–bp2 regions, and the corresponding duplications were classified as benign in this cohort. Published penetrance estimates also depend on how the phenotype is defined and how penetrance is calculated. For example, reported a pooled penetrance estimate of 51% for bcr/mapk1-containing distal 22q11.2 duplications, whereas their subsequent analysis, using a revised definition and formula focused on intellectual disability, yielded an estimate of 24% (). More broadly, the later study reported lower estimates for many low-to moderate-penetrance cnvs and discussed proposals against prenatal reporting of distal 16p11.2 duplications. This evolving evidence has broader implications for recurrent-cnv interpretation. Selected findings in our cohort illustrate distinct issues: uncertain phenotypic prediction for inherited prenatal 22q11.23 distal type iii (f–g) duplications, and debated prenatal reportability of distal 16p11.2 (bp2–bp3) duplications, represented here by a single vus. These examples illustrate why clinical interpretation depends on evidence specific to the genomic interval and phenotype, rather than on the recurrent-region label alone. These literature-based estimates were not used to assign pathogenicity; acmg/clingen scoring remained the basis for classification throughout (). Clinical implications can differ even when both dosage states are classified as pathogenic: proximal 22q11.2 deletions cause digeorge/velocardiofacial syndrome, whereas reciprocal duplications show variable expression and are often inherited (xue et al., 2021). For patient-specific clinical interpretation, region, dosage direction, inheritance, and phenotype concordance should be considered alongside the assigned classification, particularly for inherited duplications and reduced-penetrance loci in the prenatal setting.
within the prenatal cohort, 5/6 de novo findings (83.33%) and 2/11 inherited findings (18.18%) were pathogenic, while 9/11 inherited findings (81.82%) were of uncertain significance or benign. These distributions are descriptive and based on small numbers. At the individual-case level, cnv–phenotype concordance varied. Discordant examples included a 15q11.2 bp1–bp2 deletion in a fetus with omphalocele (f005), a proximal 16p11.2 deletion in a fetus with myelomeningocele and chiari ii malformation (f008), a phenotype outside the craniocervical and posterior fossa spectrum described at this locus (), and a benign xp22.31 duplication in a fetus with shortened long bones (f017). Concordant examples included the 22q11.2 deletion with conotruncal and nuchal findings (f010), the distal 1q21.1 deletion with left-sided cardiac hypoplasia (f004), the 17q12/hnf1b deletion with the renal phenotype (f009) (verscaj et al., 2024), and the xp22.31/sts deletion detected through low maternal estriol (f015) (). A pathogenic classification does not, by itself, establish that a cnv explains the fetal ultrasound findings; the inherited 22q11.23 distal type iii duplications (f011–f014) illustrate the converse, where recurrence risk is clear but outcome is not (). Prenatal clinical interpretation should therefore consider the assigned classification alongside fetal imaging, inheritance, dosage direction, and region-specific penetrance.
a key practical takeaway from this study is that reporting of recurrent cnvs can be standardized beyond local naming conventions. By anchoring each call to a clingen-curated region, maintaining dosage direction, and recording inheritance, retrospective lab results can be harmonized into a more consistent cytogenomic dataset. This is especially important for adjacent or partially overlapping recurrent intervals, such as 16p11.2 proximal (bp4–bp5; 12 carriers, all pathogenic) versus 16p11.2 distal (bp2–bp3; 2 carriers, including a vus duplication), and the 22q11.21 proximal (digeorge) region versus the 22q11.21 (ces), 22q11.21 central and 22q11.23 distal regions, where imprecise naming can obscure clinically relevant differences. Implementing a structured reporting approach that includes the reference recurrent region, dosage direction, the assigned acmg/clingen classification, clingen haploinsufficiency/triplosensitivity evidence, inheritance, and phenotype concordance is particularly important for prenatal findings and low-penetrance or inherited events.
4.1 limitations
this study has several limitations. Its retrospective, single-center design reflects local referral patterns, testing resources, and clinical triage practices. The observed recurrent-cnv frequencies are specific to this clinical cma referral cohort and cannot be used to estimate population prevalence. The postnatal and prenatal cohorts differed in size, study period, and ascertainment, so they are described in parallel rather than treated as equivalent diagnostic populations; observed differences, including dosage-related patterns, should be interpreted as descriptive and hypothesis-generating.
we used published penetrance estimates only for interpretive context, because we could not estimate penetrance from this cohort, which lacks a control population. Subgroup analyses were constrained by small denominators, particularly for targeted, confirmatory, and smaller referral categories, resulting in wide confidence intervals, so yields by indication should not be read as phenotype-specific estimates. Referral groups were based on the primary reason for testing rather than systematic organ-specific phenotyping, limiting phenotype-specific interpretation.
the restriction to clingen-curated recurrent regions enabled a standardized audit but excluded non-recurrent pathogenic cnvs, so the full diagnostic cma spectrum is not described. Clingen dosage curations may also evolve over time, and the analysis reflects the 28 april 2026 release. The study spans two array platforms and a long diagnostic period; although canonical recurrent regions are less likely to be affected by platform differences, changes in resolution, reporting thresholds, and referral practice may have influenced the broader pathogenic/likely pathogenic cnv spectrum. Systematic clinical follow-up, pregnancy outcomes, and postnatal outcomes were unavailable for prenatal cases. We derived parental phenotype from referral records rather than systematic clinical assessment, and affected transmitting parents may therefore be underestimated in the postnatal cohort. Finally, patients investigated exclusively by fish or mlpa were outside the scope of this cma-based study. Such testing pathways may therefore reduce the representation of clinically recognizable recurrent syndromes in a cma-based series.
statements
data availability statement
the original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding author.
ethics statement
the studies involving humans were approved by non-interventional scientific research ethics committee of trakya university faculty of medicine, edirne, türkiye (approval number: tÜtf-gobaek 2026/170). The studies were conducted in accordance with the local legislation and institutional requirements. Written informed consent for participation in this study was provided by the participants or their legal guardians/next of kin.
author contributions
nbs: formal analysis, writing – original draft, conceptualization, data curation. Ea: data curation, investigation, writing – review and editing, formal analysis. Sy: data curation, writing – review and editing, investigation. KmÇ: data curation, investigation, writing – review and editing. Hg: writing – review and editing, supervision, conceptualization.
funding
the author(s) declared that financial support was not received for this work and/or its publication.
conflict of interest
the author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
generative ai statement
the author(s) declared that generative ai was used in the creation of this manuscript. The authors acknowledge the use of generative ai tools (chatgpt-5.5 and notebooklm) for language improvement and literature organization. All content has been critically reviewed, edited, and validated by the authors, who take full responsibility for the final manuscript.
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publisher’s note
all claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
supplementary material
the supplementary material for this article can be found online at: https://www.Frontiersin.Org/articles/10.3389/fgene.2026.1960791/full#supplementary-material
the 48 clingen-curated recurrent regions used in this study, with isca identifiers, grch38 coordinates, haploinsufficiency/triplosensitivity scores, region labels and pooled penetrance estimates.
supplementary table s2cnv-level and case-level data for all recurrent cnv carriers (110 events in 109 carriers), including acmg/clingen dosage scores, evidence codes and final classification.
references
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summary
keywords
chromosomal microarray analysis, clingen dosage sensitivity map, constitutional cytogenomics, copy-number variation, dosage sensitivity, postnatal diagnosis, prenatal diagnosis, recurrent genomic disorder regions
citation
satk?N nb, atl? E, yalcintepe s, Çelik km and gürkan h (2026) recurrent cnvs in constitutional cma: a clingen-anchored single-center postnatal and prenatal experience. Front. Genet. 17:1960791. Doi: 10.3389/fgene.2026.1960791
received
06 august 2026
revised
27 september 2026
accepted
28 september 2026
published
20 october 2026
volume
17 - 2026
edited by
arijit panda, university of minnesota twin cities, united states
reviewed by
pamela magini, sant’orsola-malpighi polyclinic, italy
yanlin huang, guangdong province women and children hospital, china
nela maksimovic, university of belgrade, serbia
updates
copyright
© 2026 satk?N, atl?, Yalcintepe, Çelik and gürkan.
this is an open-access article distributed under the terms of the creative commons attribution license (cc by). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*correspondence: nihan bilge satk?N, bilgenihan@gmail.Com
disclaimer
all claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher. |
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